Sputum biomarkers in IPF: Evidence for raised gene expression and protein level of IGFBP-2, IL-8 and MMP-7

Idiopathic pulmonary fibrosis (IPF) is a rare lung disease of unknown origin leading rapidly to death. This paper addresses the issue of whether sputum induction is a suitable tool to study respiratory tract inflammation and potential biomarkers in IPF compared to COPD, a fibrosing airway wall disea...

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Veröffentlicht in:	PloS one 2017-02, Vol.12 (2), p.e0171344-e0171344
Hauptverfasser:	Guiot, J, Henket, M, Corhay, J L, Moermans, C, Louis, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Ambulatory care Biological markers Biology and Life Sciences Biomarkers Cardiovascular & respiratory systems Chronic obstructive pulmonary disease Cross-Sectional Studies Cytokines Diagnosis Eosinophils Epithelial cells Female Fibrosis Gelatinase B Gene Expression Genetic aspects Human health sciences Humans Idiopathic Pulmonary Fibrosis - diagnosis Idiopathic Pulmonary Fibrosis - genetics Idiopathic Pulmonary Fibrosis - metabolism Inflammation Insulin-Like Growth Factor Binding Protein 2 - genetics Insulin-Like Growth Factor Binding Protein 2 - metabolism Insulin-like growth factor I Insulin-like growth factor-binding protein 1 Insulin-like growth factor-binding protein 2 Insulin-like growth factor-binding protein 3 Insulin-like growth factors Interleukin 13 Interleukin 6 Interleukin 8 Interleukin-8 - genetics Interleukin-8 - metabolism IPF Kinases Leukocyte Count Leukocytes (eosinophilic) Leukocytes (neutrophilic) Lung diseases Macrophages Male Matrilysin Matrix Metalloproteinase 7 - genetics Matrix Metalloproteinase 7 - metabolism Medicine and Health Sciences Patients Proteins Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - genetics Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary fibrosis Research and Analysis Methods Respiratory Function Tests Respiratory tract Respiratory tract diseases Sarcoidosis Sciences de la santé humaine Sputum Sputum - cytology Sputum - metabolism Surfactants Systèmes cardiovasculaire & respiratoire Tumor necrosis factor-α
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