TNFα alters occludin and cerebral endothelial permeability: Role of p38MAPK

Occludin is a key tight junction (TJ) protein in cerebral endothelial cells (CECs) playing an important role in modulating blood-brain barrier (BBB) functions. This protein (65kDa) has been shown to engage in many signaling pathways and phosphorylation by both tyrosine and threonine kinases. Despite...

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Veröffentlicht in:	PloS one 2017-02, Vol.12 (2), p.e0170346-e0170346
Hauptverfasser:	Ni, Yawen, Teng, Tao, Li, Runting, Simonyi, Agnes, Sun, Grace Y, Lee, James C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Apoptosis Biochemistry Bioengineering Biology and Life Sciences Blood-brain barrier Blood-Brain Barrier - metabolism Brain research Cell Line Cell morphology Cell Survival - drug effects Cerebral Cortex - metabolism Cytokines Cytology Dextran Diabetic retinopathy Electrophysiological Phenomena Endothelial cells Endothelial Cells - metabolism Extracellular signal-regulated kinase Gene Expression Humans IL-1β Immunology Inflammation Inhibitors Interleukin-1beta - metabolism Interleukin-1beta - pharmacology Kinases Lipopolysaccharides Lipopolysaccharides - immunology MAP Kinase Signaling System - drug effects Medicine and Health Sciences Morphology Occludin - genetics Occludin - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Permeability Phosphorylation Physical Sciences Physiology Proteins R&D Research & development Research and Analysis Methods Signal Transduction - drug effects Signaling Stimulation Threonine Tight Junctions - metabolism Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-TNF Tumor necrosis factor-α Tyrosine
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