Integrin-dependent cell adhesion to neutrophil extracellular traps through engagement of fibronectin in neutrophil-like cells

Neutrophil extracellular traps (NETs), originally recognized as a host defense mechanism, were reported to promote thrombosis and metastatic dissemination of cancer cells. Here we tested the role of integrins α5β1 and ανβ3 in the adhesion of cancer cells to NETs. Neutrophil-like cells stimulated wit...

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Veröffentlicht in:	PloS one 2017-02, Vol.12 (2), p.e0171362-e0171362
Hauptverfasser:	Monti, Marcello, Iommelli, Francesca, De Rosa, Viviana, Carriero, Maria Vincenza, Miceli, Roberta, Camerlingo, Rosa, Di Minno, Giovanni, Del Vecchio, Silvana
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Adhesion tests Adhesive strength Antibodies Binding sites Biology and Life Sciences Biomarkers Biotechnology Blocking antibodies Blood Calcimycin Calcium Cancer Cancer cells Cell Adhesion Cell adhesion & migration Citrulline Confocal microscopy Deoxyribonuclease Deoxyribonucleic acid DNA Endopeptidase K Extracellular matrix Extracellular Traps - metabolism Fibronectin Fibronectins - metabolism Gene expression Genetic aspects Health aspects Histone H3 Histones - metabolism Humans Immune response Immunoprecipitation Integrins Integrins - metabolism Kinases Leukocytes (neutrophilic) Ligands Medicine and Health Sciences Metastases Metastasis Microscopy Neutrophils Neutrophils - physiology Peroxidase - metabolism Physical Sciences Platelets Protein Binding Protein Transport Proteinase Proteins Research and Analysis Methods Substrates Thromboembolism Thrombosis
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