Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism

Human CD4 T cells are constantly exposed to IL-12 during infections and certain autoimmune disorders. The current paradigm is that IL-12 promotes the differentiation of naïve CD4 T cells into Th1 cells, but recent studies suggest IL-12 may play a more complex role in T cell biology. We examined if e...

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Veröffentlicht in:	PloS one 2016-06, Vol.11 (6), p.e0157175
Hauptverfasser:	Vacaflores, Aldo, Chapman, Nicole M, Harty, John T, Richer, Martin J, Houtman, Jon C D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult AKT protein Autoimmune diseases Biology and Life Sciences CD4 antigen CD4-Positive T-Lymphocytes - metabolism Cytokines Cytokines - immunology Exposure Female Genetic aspects Health aspects Humans Interferon Interleukin 10 Interleukin 12 Interleukin 13 Interleukin 4 Interleukin-12 - pharmacology Lck protein Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - immunology Lymphocytes Lymphocytes T Male Medicine and Health Sciences Metabolism Middle Aged Oxidation-Reduction - drug effects Oxidative metabolism p38 Mitogen-Activated Protein Kinases - immunology Phosphorylation Phosphorylation - drug effects Phosphorylation - immunology Physiological aspects Post-transcription Proto-Oncogene Proteins c-akt - immunology Receptors, Antigen, T-Cell - immunology Research and Analysis Methods Signal Transduction - drug effects Signal Transduction - immunology Signaling Stimulation T cell antigen receptors T cell receptors T cells T-cell receptor Transcription, Genetic - drug effects Transcription, Genetic - immunology Tumor necrosis factor Tumor necrosis factor-α γ-Interferon
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