Optical Coherence Tomography Angiography Findings in Stargardt Disease
to assess vessel density of superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris (CC) in advanced Stargardt disease (STGD) using optical coherence tomography angiography (OCTA) and correlate these findings with macular function using pattern electroretinogram (PERG) a...
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| creator | Mastropasqua, Rodolfo Toto, Lisa Borrelli, Enrico Di Antonio, Luca Mattei, Peter A Senatore, Alfonso Di Nicola, Marta Mariotti, Cesare |
| description | to assess vessel density of superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris (CC) in advanced Stargardt disease (STGD) using optical coherence tomography angiography (OCTA) and correlate these findings with macular function using pattern electroretinogram (PERG) and multifocal electroretinogram (mfERG).
Twelve patients (24 eyes) with advanced STGD underwent vessel densities and macular thickness measurements using OCTA. A control group of 24 healthy controls (24 eyes) was chosen for comparison. In the STGD group correlation between vessel density and macular thickness and between macular function and morphologic parameters were evaluated.
Whole parafoveal vessel density (VD) of SCP was significantly lower in STGD group compared to the control group (p |
| doi_str_mv | 10.1371/journal.pone.0170343 |
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Twelve patients (24 eyes) with advanced STGD underwent vessel densities and macular thickness measurements using OCTA. A control group of 24 healthy controls (24 eyes) was chosen for comparison. In the STGD group correlation between vessel density and macular thickness and between macular function and morphologic parameters were evaluated.
Whole parafoveal vessel density (VD) of SCP was significantly lower in STGD group compared to the control group (p<0.05). Foveal VD and whole parafoveal VD of the DCP were significantly lower in STGD group compared to the controls (p<0.05). CC was significantly decreased in STGD compared to controls (p<0.05). Foveal macular thickness (MT), full parafoveal MT, and inner limiting membrane (ILM)-inner plexiform layer (IPL) parafoveal MT thickness were decreased in STGD eyes compared to controls (p<0.001). PERG and mfERG were both significantly reduced in STGD compared to controls (p<0.001). A direct correlation was found between full parafoveal MT and vessel density in the STGD group.
Patients with advanced STGD showed a reduction of SCP, DCP and CC compared to healthy eyes related to a reduction of total and ILM-IPL macular thickness. These results suggest that both retinal capillaris plexuses and choriocapillaris reduction occur in STDG along with inner and outer retinal thinning.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0170343</identifier><identifier>PMID: 28151966</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Aged ; Aging ; Analysis ; Angiography ; Angiography - methods ; Biology and Life Sciences ; Capillaries ; Case-Control Studies ; Correlation ; Density ; Diabetes ; Diabetic retinopathy ; Disease ; Electroretinography - methods ; Eye ; Eye (anatomy) ; Female ; Health aspects ; Humans ; Macula Lutea - diagnostic imaging ; Macula Lutea - physiopathology ; Macular degeneration ; Macular Degeneration - congenital ; Macular Degeneration - diagnostic imaging ; Macular Degeneration - physiopathology ; Male ; Medical imaging ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Optical Coherence Tomography ; Patients ; Photoreceptors ; Reduction ; Research and Analysis Methods ; Retina ; Retinal Vessels - diagnostic imaging ; Science ; Sexually transmitted diseases ; STD ; Thickness measurement ; Tomography ; Tomography, Optical Coherence - methods ; Young Adult</subject><ispartof>PloS one, 2017-02, Vol.12 (2), p.e0170343-e0170343</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Mastropasqua et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Mastropasqua et al 2017 Mastropasqua et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-dfb3c585e95ea9f1ed5d178fd14cbbddf06444872bb8c6be88c1c5bcc51281a13</citedby><cites>FETCH-LOGICAL-c725t-dfb3c585e95ea9f1ed5d178fd14cbbddf06444872bb8c6be88c1c5bcc51281a13</cites><orcidid>0000-0001-5311-5184</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289432/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289432/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2106,2932,23875,27933,27934,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28151966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ablonczy, Zsolt</contributor><creatorcontrib>Mastropasqua, Rodolfo</creatorcontrib><creatorcontrib>Toto, Lisa</creatorcontrib><creatorcontrib>Borrelli, Enrico</creatorcontrib><creatorcontrib>Di Antonio, Luca</creatorcontrib><creatorcontrib>Mattei, Peter A</creatorcontrib><creatorcontrib>Senatore, Alfonso</creatorcontrib><creatorcontrib>Di Nicola, Marta</creatorcontrib><creatorcontrib>Mariotti, Cesare</creatorcontrib><title>Optical Coherence Tomography Angiography Findings in Stargardt Disease</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>to assess vessel density of superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris (CC) in advanced Stargardt disease (STGD) using optical coherence tomography angiography (OCTA) and correlate these findings with macular function using pattern electroretinogram (PERG) and multifocal electroretinogram (mfERG).
Twelve patients (24 eyes) with advanced STGD underwent vessel densities and macular thickness measurements using OCTA. A control group of 24 healthy controls (24 eyes) was chosen for comparison. In the STGD group correlation between vessel density and macular thickness and between macular function and morphologic parameters were evaluated.
Whole parafoveal vessel density (VD) of SCP was significantly lower in STGD group compared to the control group (p<0.05). Foveal VD and whole parafoveal VD of the DCP were significantly lower in STGD group compared to the controls (p<0.05). CC was significantly decreased in STGD compared to controls (p<0.05). Foveal macular thickness (MT), full parafoveal MT, and inner limiting membrane (ILM)-inner plexiform layer (IPL) parafoveal MT thickness were decreased in STGD eyes compared to controls (p<0.001). PERG and mfERG were both significantly reduced in STGD compared to controls (p<0.001). A direct correlation was found between full parafoveal MT and vessel density in the STGD group.
Patients with advanced STGD showed a reduction of SCP, DCP and CC compared to healthy eyes related to a reduction of total and ILM-IPL macular thickness. These results suggest that both retinal capillaris plexuses and choriocapillaris reduction occur in STDG along with inner and outer retinal thinning.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aging</subject><subject>Analysis</subject><subject>Angiography</subject><subject>Angiography - methods</subject><subject>Biology and Life Sciences</subject><subject>Capillaries</subject><subject>Case-Control Studies</subject><subject>Correlation</subject><subject>Density</subject><subject>Diabetes</subject><subject>Diabetic retinopathy</subject><subject>Disease</subject><subject>Electroretinography - methods</subject><subject>Eye</subject><subject>Eye (anatomy)</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Macula Lutea - diagnostic imaging</subject><subject>Macula Lutea - physiopathology</subject><subject>Macular degeneration</subject><subject>Macular Degeneration - congenital</subject><subject>Macular Degeneration - diagnostic imaging</subject><subject>Macular Degeneration - physiopathology</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Optical Coherence Tomography</subject><subject>Patients</subject><subject>Photoreceptors</subject><subject>Reduction</subject><subject>Research and Analysis Methods</subject><subject>Retina</subject><subject>Retinal Vessels - diagnostic imaging</subject><subject>Science</subject><subject>Sexually transmitted diseases</subject><subject>STD</subject><subject>Thickness measurement</subject><subject>Tomography</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12LEzEUhgdR3A_9B6IDguhFazKZTDI3QqlWCwsFd_U2ZJIz05RpUpMZcf_9ptvp0pG9WHKRkDzvm3NOcpLkDUZTTBj-vHG9t7Kd7pyFKcIMkZw8S85xSbJJkSHy_GR9llyEsEGIEl4UL5OzjGOKy6I4TxarXWeUbNO5W4MHqyC9cVvXeLlb36Yz25jjemGsNrYJqbHpdSd9I73u0q8mgAzwKnlRyzbA62G-TH4tvt3Mf0yuVt-X89nVRLGMdhNdV0RRTqGkIMsag6YaM15rnKuq0rpGRZ7nnGVVxVVRAecKK1opRXEMWWJymbw7-O5aF8RQgiAwjzpEUc4jsTwQ2smN2Hmzlf5WOGnE_YbzjZA-ptyC0CVoVWhgGKMcdCkxo4yUKuOlrOq8iF5fhtv6ahtZsJ2X7ch0fGLNWjTur6DRIidZNPg4GHj3p4fQia0JCtpWWnD9fdyckCJn5VNQSjFHbJ_i-__QxwsxUI2MuRpbuxii2puKWbyQ0bJA-4JOH6Hi0LA1Kn6t2sT9keDTSBCZDv51jexDEMvrn09nV7_H7IcTdg2y7dbBtX1nnA1jMD-AyrsQPNQP74GR2HfGsRpi3xli6Iwoe3v6lg-iYyuQO_73CJk</recordid><startdate>20170202</startdate><enddate>20170202</enddate><creator>Mastropasqua, Rodolfo</creator><creator>Toto, Lisa</creator><creator>Borrelli, Enrico</creator><creator>Di Antonio, Luca</creator><creator>Mattei, Peter A</creator><creator>Senatore, Alfonso</creator><creator>Di Nicola, Marta</creator><creator>Mariotti, Cesare</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5311-5184</orcidid></search><sort><creationdate>20170202</creationdate><title>Optical Coherence Tomography Angiography Findings in Stargardt Disease</title><author>Mastropasqua, Rodolfo ; Toto, Lisa ; Borrelli, Enrico ; Di Antonio, Luca ; Mattei, Peter A ; Senatore, Alfonso ; Di Nicola, Marta ; Mariotti, Cesare</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c725t-dfb3c585e95ea9f1ed5d178fd14cbbddf06444872bb8c6be88c1c5bcc51281a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aging</topic><topic>Analysis</topic><topic>Angiography</topic><topic>Angiography - methods</topic><topic>Biology and Life Sciences</topic><topic>Capillaries</topic><topic>Case-Control Studies</topic><topic>Correlation</topic><topic>Density</topic><topic>Diabetes</topic><topic>Diabetic retinopathy</topic><topic>Disease</topic><topic>Electroretinography - methods</topic><topic>Eye</topic><topic>Eye (anatomy)</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Macula Lutea - diagnostic imaging</topic><topic>Macula Lutea - physiopathology</topic><topic>Macular degeneration</topic><topic>Macular Degeneration - congenital</topic><topic>Macular Degeneration - diagnostic imaging</topic><topic>Macular Degeneration - physiopathology</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Optical Coherence Tomography</topic><topic>Patients</topic><topic>Photoreceptors</topic><topic>Reduction</topic><topic>Research and Analysis Methods</topic><topic>Retina</topic><topic>Retinal Vessels - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mastropasqua, Rodolfo</au><au>Toto, Lisa</au><au>Borrelli, Enrico</au><au>Di Antonio, Luca</au><au>Mattei, Peter A</au><au>Senatore, Alfonso</au><au>Di Nicola, Marta</au><au>Mariotti, Cesare</au><au>Ablonczy, Zsolt</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optical Coherence Tomography Angiography Findings in Stargardt Disease</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-02-02</date><risdate>2017</risdate><volume>12</volume><issue>2</issue><spage>e0170343</spage><epage>e0170343</epage><pages>e0170343-e0170343</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>to assess vessel density of superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris (CC) in advanced Stargardt disease (STGD) using optical coherence tomography angiography (OCTA) and correlate these findings with macular function using pattern electroretinogram (PERG) and multifocal electroretinogram (mfERG).
Twelve patients (24 eyes) with advanced STGD underwent vessel densities and macular thickness measurements using OCTA. A control group of 24 healthy controls (24 eyes) was chosen for comparison. In the STGD group correlation between vessel density and macular thickness and between macular function and morphologic parameters were evaluated.
Whole parafoveal vessel density (VD) of SCP was significantly lower in STGD group compared to the control group (p<0.05). Foveal VD and whole parafoveal VD of the DCP were significantly lower in STGD group compared to the controls (p<0.05). CC was significantly decreased in STGD compared to controls (p<0.05). Foveal macular thickness (MT), full parafoveal MT, and inner limiting membrane (ILM)-inner plexiform layer (IPL) parafoveal MT thickness were decreased in STGD eyes compared to controls (p<0.001). PERG and mfERG were both significantly reduced in STGD compared to controls (p<0.001). A direct correlation was found between full parafoveal MT and vessel density in the STGD group.
Patients with advanced STGD showed a reduction of SCP, DCP and CC compared to healthy eyes related to a reduction of total and ILM-IPL macular thickness. These results suggest that both retinal capillaris plexuses and choriocapillaris reduction occur in STDG along with inner and outer retinal thinning.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28151966</pmid><doi>10.1371/journal.pone.0170343</doi><tpages>e0170343</tpages><orcidid>https://orcid.org/0000-0001-5311-5184</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2017-02, Vol.12 (2), p.e0170343-e0170343 |
| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Age Aged Aging Analysis Angiography Angiography - methods Biology and Life Sciences Capillaries Case-Control Studies Correlation Density Diabetes Diabetic retinopathy Disease Electroretinography - methods Eye Eye (anatomy) Female Health aspects Humans Macula Lutea - diagnostic imaging Macula Lutea - physiopathology Macular degeneration Macular Degeneration - congenital Macular Degeneration - diagnostic imaging Macular Degeneration - physiopathology Male Medical imaging Medicine Medicine and Health Sciences Middle Aged Optical Coherence Tomography Patients Photoreceptors Reduction Research and Analysis Methods Retina Retinal Vessels - diagnostic imaging Science Sexually transmitted diseases STD Thickness measurement Tomography Tomography, Optical Coherence - methods Young Adult |
| title | Optical Coherence Tomography Angiography Findings in Stargardt Disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-03T12%3A23%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Optical%20Coherence%20Tomography%20Angiography%20Findings%20in%20Stargardt%20Disease&rft.jtitle=PloS%20one&rft.au=Mastropasqua,%20Rodolfo&rft.date=2017-02-02&rft.volume=12&rft.issue=2&rft.spage=e0170343&rft.epage=e0170343&rft.pages=e0170343-e0170343&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0170343&rft_dat=%3Cgale_plos_%3EA479759601%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1864405048&rft_id=info:pmid/28151966&rft_galeid=A479759601&rft_doaj_id=oai_doaj_org_article_d9edc6de71104ed9a175739c289abf46&rfr_iscdi=true |