NKL homeobox gene activities in hematopoietic stem cells, T-cell development and T-cell leukemia

T-cell acute lymphoblastic leukemia (T-ALL) cells represent developmentally arrested T-cell progenitors, subsets of which aberrantly express homeobox genes of the NKL subclass, including TLX1, TLX3, NKX2-1, NKX2-5, NKX3-1 and MSX1. Here, we analyzed the transcriptional landscape of all 48 members of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2017-02, Vol.12 (2), p.e0171164-e0171164
Hauptverfasser:	Nagel, Stefan, Pommerenke, Claudia, Scherr, Michaela, Meyer, Corinna, Kaufmann, Maren, Battmer, Karin, MacLeod, Roderick A F, Drexler, Hans G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Acute lymphoblastic leukemia Acute lymphocytic leukemia Apoptosis Apoptosis - genetics Biology and Life Sciences Cancer CD34 antigen Cell culture Cell Differentiation - genetics Cell Line, Tumor Cells (biology) Cells, Cultured Deregulation Ectopic expression Gene expression Gene Expression Profiling Gene regulation Gene Regulatory Networks Genes Genes, Homeobox Genetic aspects Hematology Hematopoiesis Hematopoiesis - genetics Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Homeobox Homeodomain Proteins - genetics Humans Leukemia Lymphatic leukemia Lymphocytes T Lymphoma Lymphopoiesis Lymphopoiesis - genetics Medicine and Health Sciences Microorganisms MSX1 Transcription Factor - genetics Nkx2.3 protein Nkx2.5 protein Physiology Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology Progenitor cells Proteins Stem cells T cell receptors T cells T-Lymphocytes - cytology T-Lymphocytes - metabolism Thyroid transcription factor 1 Tlx1 protein Tlx3 protein Transcription Transcription Factors - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!