Establishing a reference interval for serum anti-dsDNA antibody: A large Chinese Han population-based multi-center study
A reference interval (RI) for the circulating concentration of anti-dsDNA antibody is essential for clinicians to interpret laboratory results and make clinical decisions. Therefore, we aimed to establish the RI for anti-dsDNA antibody in the Chinese Han population. This study was designed and carri...
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| Veröffentlicht in: | PloS one 2017-02, Vol.12 (2), p.e0168871-e0168871 |
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| creator | Deng, Chuiwen Zhang, Shulan Hu, Chaojun Li, Ping Wu, Ziyan Chen, Si Li, Jing Li, Liubing Zhang, Fengchun Li, Yongzhe |
| description | A reference interval (RI) for the circulating concentration of anti-dsDNA antibody is essential for clinicians to interpret laboratory results and make clinical decisions. Therefore, we aimed to establish the RI for anti-dsDNA antibody in the Chinese Han population.
This study was designed and carried out in accordance with guideline C28-A3, which is proposed by the International Federation of Clinical Chemistry and the Clinical and Laboratory Standards Institute. A total of 2,880 apparently healthy individuals were enrolled using a posteriori sampling. These individuals were recruited from four hospitals, representing the Han populations of north, south, east, and west China. Serum anti-dsDNA antibody levels were measured using the three analytical systems AESKU, EUROIMMUNE, and INOVA, which are the most commonly used systems in China. Individuals were stratified by gender, age, and region, and the RIs were obtained by nonparametric methods.
Gender-specific RIs for serum anti-dsDNA antibody in the Chinese Han population were established.
This is the first exploration of the RI for anti-dsDNA antibody in the Chinese Han population. We have established gender-specific RIs for each assay method commonly used in China. |
| doi_str_mv | 10.1371/journal.pone.0168871 |
| format | Article |
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This study was designed and carried out in accordance with guideline C28-A3, which is proposed by the International Federation of Clinical Chemistry and the Clinical and Laboratory Standards Institute. A total of 2,880 apparently healthy individuals were enrolled using a posteriori sampling. These individuals were recruited from four hospitals, representing the Han populations of north, south, east, and west China. Serum anti-dsDNA antibody levels were measured using the three analytical systems AESKU, EUROIMMUNE, and INOVA, which are the most commonly used systems in China. Individuals were stratified by gender, age, and region, and the RIs were obtained by nonparametric methods.
Gender-specific RIs for serum anti-dsDNA antibody in the Chinese Han population were established.
This is the first exploration of the RI for anti-dsDNA antibody in the Chinese Han population. We have established gender-specific RIs for each assay method commonly used in China.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0168871</identifier><identifier>PMID: 28151970</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-DNA antibodies ; Antibodies ; Antibodies, Antinuclear - blood ; Asian Continental Ancestry Group ; Autoimmune diseases ; Binding sites ; Biology and Life Sciences ; Care and treatment ; China ; Computer and Information Sciences ; Diagnosis ; Education ; Enzyme-linked immunosorbent assay ; Ethnic Groups ; Female ; Gender ; Healthy Volunteers ; Hospitals ; Humans ; Immunoglobulins ; Immunology ; International standardization ; Laboratories ; Lupus ; Male ; Medical research ; Medicine and Health Sciences ; Middle Aged ; People and Places ; Physicians ; Population ; Population studies ; Population-based studies ; Reference Values ; Rheumatology ; Studies ; Young Adult</subject><ispartof>PloS one, 2017-02, Vol.12 (2), p.e0168871-e0168871</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Deng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Deng et al 2017 Deng et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-8af09919c5013eb2cfa9bfd14319366533acd5d6411f05f8390d259a3b0149e83</citedby><cites>FETCH-LOGICAL-c725t-8af09919c5013eb2cfa9bfd14319366533acd5d6411f05f8390d259a3b0149e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289441/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289441/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28151970$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deng, Chuiwen</creatorcontrib><creatorcontrib>Zhang, Shulan</creatorcontrib><creatorcontrib>Hu, Chaojun</creatorcontrib><creatorcontrib>Li, Ping</creatorcontrib><creatorcontrib>Wu, Ziyan</creatorcontrib><creatorcontrib>Chen, Si</creatorcontrib><creatorcontrib>Li, Jing</creatorcontrib><creatorcontrib>Li, Liubing</creatorcontrib><creatorcontrib>Zhang, Fengchun</creatorcontrib><creatorcontrib>Li, Yongzhe</creatorcontrib><title>Establishing a reference interval for serum anti-dsDNA antibody: A large Chinese Han population-based multi-center study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>A reference interval (RI) for the circulating concentration of anti-dsDNA antibody is essential for clinicians to interpret laboratory results and make clinical decisions. Therefore, we aimed to establish the RI for anti-dsDNA antibody in the Chinese Han population.
This study was designed and carried out in accordance with guideline C28-A3, which is proposed by the International Federation of Clinical Chemistry and the Clinical and Laboratory Standards Institute. A total of 2,880 apparently healthy individuals were enrolled using a posteriori sampling. These individuals were recruited from four hospitals, representing the Han populations of north, south, east, and west China. Serum anti-dsDNA antibody levels were measured using the three analytical systems AESKU, EUROIMMUNE, and INOVA, which are the most commonly used systems in China. Individuals were stratified by gender, age, and region, and the RIs were obtained by nonparametric methods.
Gender-specific RIs for serum anti-dsDNA antibody in the Chinese Han population were established.
This is the first exploration of the RI for anti-dsDNA antibody in the Chinese Han population. We have established gender-specific RIs for each assay method commonly used in China.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-DNA antibodies</subject><subject>Antibodies</subject><subject>Antibodies, Antinuclear - blood</subject><subject>Asian Continental Ancestry Group</subject><subject>Autoimmune diseases</subject><subject>Binding sites</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>China</subject><subject>Computer and Information Sciences</subject><subject>Diagnosis</subject><subject>Education</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Ethnic Groups</subject><subject>Female</subject><subject>Gender</subject><subject>Healthy Volunteers</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Immunology</subject><subject>International 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Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deng, Chuiwen</au><au>Zhang, Shulan</au><au>Hu, Chaojun</au><au>Li, Ping</au><au>Wu, Ziyan</au><au>Chen, Si</au><au>Li, Jing</au><au>Li, Liubing</au><au>Zhang, Fengchun</au><au>Li, Yongzhe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Establishing a reference interval for serum anti-dsDNA antibody: A large Chinese Han population-based multi-center study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-02-02</date><risdate>2017</risdate><volume>12</volume><issue>2</issue><spage>e0168871</spage><epage>e0168871</epage><pages>e0168871-e0168871</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>A reference interval (RI) for the circulating concentration of anti-dsDNA antibody is essential for clinicians to interpret laboratory results and make clinical decisions. Therefore, we aimed to establish the RI for anti-dsDNA antibody in the Chinese Han population.
This study was designed and carried out in accordance with guideline C28-A3, which is proposed by the International Federation of Clinical Chemistry and the Clinical and Laboratory Standards Institute. A total of 2,880 apparently healthy individuals were enrolled using a posteriori sampling. These individuals were recruited from four hospitals, representing the Han populations of north, south, east, and west China. Serum anti-dsDNA antibody levels were measured using the three analytical systems AESKU, EUROIMMUNE, and INOVA, which are the most commonly used systems in China. Individuals were stratified by gender, age, and region, and the RIs were obtained by nonparametric methods.
Gender-specific RIs for serum anti-dsDNA antibody in the Chinese Han population were established.
This is the first exploration of the RI for anti-dsDNA antibody in the Chinese Han population. We have established gender-specific RIs for each assay method commonly used in China.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28151970</pmid><doi>10.1371/journal.pone.0168871</doi><tpages>e0168871</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Anti-DNA antibodies Antibodies Antibodies, Antinuclear - blood Asian Continental Ancestry Group Autoimmune diseases Binding sites Biology and Life Sciences Care and treatment China Computer and Information Sciences Diagnosis Education Enzyme-linked immunosorbent assay Ethnic Groups Female Gender Healthy Volunteers Hospitals Humans Immunoglobulins Immunology International standardization Laboratories Lupus Male Medical research Medicine and Health Sciences Middle Aged People and Places Physicians Population Population studies Population-based studies Reference Values Rheumatology Studies Young Adult |
| title | Establishing a reference interval for serum anti-dsDNA antibody: A large Chinese Han population-based multi-center study |
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