KChIP2 genotype dependence of transient outward current (Ito) properties in cardiomyocytes isolated from male and female mice

The transient outward current (Ito) in cardiomyocytes is largely mediated by Kv4 channels associated with Kv Channel Interacting Protein 2 (KChIP2). A knockout model has documented the critical role of KChIP2 in Ito expression. The present study was conducted to characterize in both sexes the depend...

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Veröffentlicht in:	PloS one 2017-01, Vol.12 (1), p.e0171213-e0171213
Hauptverfasser:	Waldschmidt, Lara, Junkereit, Vera, Bähring, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Biology and Life Sciences Cardiology Cardiomyocytes Cell Separation Channel gating Deactivation Dosage Electric potential Female Gene dosage Gene expression Genetic aspects Genotype Genotypes Heart Heart cells Inactivation Ion Channel Gating - genetics Kinetics Kv Channel-Interacting Proteins - deficiency Kv Channel-Interacting Proteins - genetics Kv Channel-Interacting Proteins - metabolism Male Medicine and Health Sciences Mice Mice, Inbred C57BL Myocytes Myocytes, Cardiac - metabolism Oocytes Physical Sciences Physiological aspects Physiology Potassium channels Potassium channels (voltage-gated) Properties (attributes) Proteins Recovery Research and Analysis Methods Rodents Shal Potassium Channels - metabolism Ventricle Xenopus
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