Knockdown of Mediator Complex Subunit 19 Suppresses the Growth and Invasion of Prostate Cancer Cells

Prostate cancer (PCa) is one of the most common cancers in elderly men. Mediator Complex Subunit 19 (Med19) is overexpressed and plays promotional roles in many cancers. However, the roles of Med19 in PCa are still obscure. In this study, by using immunohistochemical staining, we found higher expres...

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Veröffentlicht in:	PloS one 2017-01, Vol.12 (1), p.e0171134-e0171134
Hauptverfasser:	Yu, Shengqiang, Wang, Yanwei, Yuan, Hejia, Zhao, Hongwei, Lv, Wei, Chen, Jian, Wan, Fengchun, Liu, Dongfu, Gao, Zhenli, Wu, Jitao
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Androgens Animal tissues Animals Biology and Life Sciences Cancer Cancer cells Cell cycle Cell growth Cell migration Cell Movement - genetics Cell proliferation Cell Proliferation - genetics E-cadherin Elderly Epithelial-Mesenchymal Transition Genetic aspects Genetic regulation Genetically modified mice Geriatrics Health aspects Heterografts Humans Kinases Laboratories Lentivirus Male Mediator Complex - genetics Mediator Complex - metabolism Medicine and Health Sciences Mesenchyme Metastases Mice Mice, Nude N-Cadherin Neoplasm Invasiveness - genetics Older people Prostate - pathology Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Research and Analysis Methods Retroviridae RNA, Small Interfering siRNA Tumors Vimentin Xenografts
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