A Circulating microRNA Signature Predicts Age-Based Development of Lymphoma

Extensive epidemiological data have demonstrated an exponential rise in the incidence of non-Hodgkin lymphoma (NHL) that is associated with increasing age. The molecular etiology of this remains largely unknown, which impacts the effectiveness of treatment for patients. We proposed that age-dependen...

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Veröffentlicht in:	PloS one 2017-01, Vol.12 (1), p.e0170521
Hauptverfasser:	Beheshti, Afshin, Vanderburg, Charles, McDonald, J Tyson, Ramkumar, Charusheila, Kadungure, Tatenda, Zhang, Hong, Gartenhaus, Ronald B, Evens, Andrew M
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age Factors Analysis Animal models Animals B-cell lymphoma Biology Biology and life sciences Blood circulation Blotting, Western Bone marrow Bone Marrow - metabolism Cancer Carcinogens Development and progression Epidemiology Etiology Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Hematology Humans Lymphocytes B Lymphoma Lymphoma, Large B-Cell, Diffuse - etiology Lymphomas Medical innovations Medical prognosis Medical research Medical schools Medicine and Health Sciences Mice Mice, Inbred C57BL MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - physiology miRNA Myc protein Oncology Polymerase Chain Reaction Research and Analysis Methods Ribonucleic acid Risk assessment RNA Signaling Signatures Spleen Spleen - metabolism Tumors Ubiquitin-Protein Ligases - deficiency
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