Peptide Targeted by Human Antibodies Associated with HIV Vaccine-Associated Protection Assumes a Dynamic α-Helical Structure

The only evidence of vaccine-induced protection from HIV acquisition in humans was obtained in the RV144 HIV vaccine clinical trial. One immune correlate of risk in RV144 was observed to be higher titers of vaccine-induced antibodies (Abs) reacting with a 23-mer non-glycosylated peptide with the sam...

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Veröffentlicht in:	PloS one 2017-01, Vol.12 (1), p.e0170530-e0170530
Hauptverfasser:	Aiyegbo, Mohammed S, Shmelkov, Evgeny, Dominguez, Lorenzo, Goger, Michael, Battacharya, Shibani, deCamp, Allan C, Gilbert, Peter B, Berman, Phillip W, Cardozo, Timothy
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Vaccines - immunology Amino Acid Sequence Amino acids Antibodies Antibodies, Neutralizing - immunology Biochemistry Biology and Life Sciences Computational chemistry Conserved Sequence - genetics Cytotoxicity Epitopes Glycoproteins HIV HIV Antibodies - immunology HIV Envelope Protein gp120 - chemistry HIV Envelope Protein gp120 - immunology HIV-1 - genetics HIV-1 - immunology Human immunodeficiency virus Humans Immunoglobulins Infections Infectious diseases Magnetic Resonance Spectroscopy Medical research Medicine Medicine and Health Sciences Models, Molecular NMR Nuclear magnetic resonance Peptide Fragments - chemistry Peptide Fragments - immunology Peptides Pharmacology Physical Sciences Protein Conformation, alpha-Helical Protein Folding Proteins Protons Research and Analysis Methods Vaccines
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