Weight Perturbation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the Brain
Diet-induced obesity (DIO) resulting from consumption of a high fat diet (HFD) attenuates normal neuronal responses to leptin and may contribute to the metabolic defense of an acquired higher body weight in humans; the molecular bases for the persistence of this defense are unknown. We measured the...
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| creator | Morabito, Michael V Ravussin, Yann Mueller, Bridget R Skowronski, Alicja A Watanabe, Kazuhisa Foo, Kylie S Lee, Samuel X Lehmann, Anders Hjorth, Stephan Zeltser, Lori M LeDuc, Charles A Leibel, Rudolph L |
| description | Diet-induced obesity (DIO) resulting from consumption of a high fat diet (HFD) attenuates normal neuronal responses to leptin and may contribute to the metabolic defense of an acquired higher body weight in humans; the molecular bases for the persistence of this defense are unknown. We measured the responses of 23 brain regions to exogenous leptin in 4 different groups of weight- and/or diet-perturbed mice. Responses to leptin were assessed by quantifying pSTAT3 levels in brain nuclei 30 minutes following 3 mg/kg intraperitoneal leptin. HFD attenuated leptin sensing throughout the brain, but weight loss did not restore central leptin signaling to control levels in several brain regions important in energy homeostasis, including the arcuate and dorsomedial hypothalamic nuclei. Effects of diet on leptin signaling varied by brain region, with results dependent on the method of weight loss (restriction of calories of HFD, ad lib intake of standard mouse chow). High fat diet attenuates leptin signaling throughout the brain, but some brain regions maintain their ability to sense leptin. Weight loss restores leptin sensing to some degree in most (but not all) brain regions, while other brain regions display hypersensitivity to leptin following weight loss. Normal leptin sensing was restored in several brain regions, with the pattern of restoration dependent on the method of weight loss. |
| doi_str_mv | 10.1371/journal.pone.0168226 |
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This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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| recordid | cdi_plos_journals_1860295704 |
| source | PLoS; MEDLINE; DOAJ Directory of Open Access Journals; SWEPUB Freely available online; Free E-Journal (出版社公開部分のみ）; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Attenuation Biology and Life Sciences Blood Glucose - metabolism Body Composition Body Weight Body weight loss Brain Brain - metabolism Brain research Calories Cellular signal transduction Detection Diabetes Diet Energy balance Energy Intake Energy Metabolism Health aspects High fat diet Homeostasis Hypersensitivity Hypothalamus Insulin - blood Leptin Leptin - metabolism Male Medicin och hälsovetenskap Medicine Medicine and Health Sciences Metabolism Mice Mice, Inbred C57BL Nervous system Neurosciences Nuclei Nutrition research Obesity Pediatrics Physiological aspects Physiology R&D Research & development Restoration Risk factors Rodents Signal Transduction Signaling Surgeons Thyroid gland Weight control Weight loss |
| title | Weight Perturbation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the Brain |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-03T14%3A41%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Weight%20Perturbation%20Alters%20Leptin%20Signal%20Transduction%20in%20a%20Region-Specific%20Manner%20throughout%20the%20Brain&rft.jtitle=PloS%20one&rft.au=Morabito,%20Michael%20V&rft.date=2017-01-20&rft.volume=12&rft.issue=1&rft.spage=e0168226&rft.epage=e0168226&rft.pages=e0168226-e0168226&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0168226&rft_dat=%3Cgale_plos_%3EA478287007%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1860295704&rft_id=info:pmid/28107353&rft_galeid=A478287007&rft_doaj_id=oai_doaj_org_article_e03bbf78f86141cca32bc013562de4ed&rfr_iscdi=true |