Systemic T Cells Immunosuppression of Glioma Stem Cell-Derived Exosomes Is Mediated by Monocytic Myeloid-Derived Suppressor Cells

A major contributing factor to glioma development and progression is its ability to evade the immune system. Nano-meter sized vesicles, exosomes, secreted by glioma-stem cells (GSC) can act as mediators of intercellular communication to promote tumor immune escape. Here, we investigated the immunomo...

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Veröffentlicht in:	PloS one 2017-01, Vol.12 (1), p.e0169932-e0169932
Hauptverfasser:	Domenis, Rossana, Cesselli, Daniela, Toffoletto, Barbara, Bourkoula, Evgenia, Caponnetto, Federica, Manini, Ivana, Beltrami, Antonio Paolo, Ius, Tamara, Skrap, Miran, Di Loreto, Carla, Gri, Giorgia
Format:	Artikel
Sprache:	eng
Schlagworte:	Arginase Biology and Life Sciences Biomarkers Brain cancer Brain Neoplasms - blood Brain Neoplasms - immunology CD14 antigen CD25 antigen CD28 antigen CD3 antigen CD4 antigen CD69 antigen Cell activation Cell culture Cell growth Cell Proliferation Cell signaling Cells, Cultured Coculture Techniques Cytokines Development and progression Effector cells Exosomes Exosomes - immunology Flow Cytometry Gene amplification Glioblastoma Glioblastoma - blood Glioblastoma - immunology Glioma Glioma cells Gliomas Growth factors Histocompatibility antigen HLA Humans Immune response Immune response (cell-mediated) Immune system Immunomodulation Immunoregulation Immunosuppression Immunotherapy Interleukin 10 Interleukin 2 Leukocytes (mononuclear) Lymphocyte Activation Lymphocytes Lymphocytes T Medicine and Health Sciences Monocytes Monocytes - immunology Neoplastic Stem Cells - immunology Neurosurgery Physiological aspects Research and Analysis Methods Risk factors Stem cells Suppressor cells T cell receptors T-Lymphocytes, Regulatory - immunology Transfer RNA Tumors
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