Significance of Serum Total Oxidant/Antioxidant Status in Patients with Colorectal Cancer
Oxidative stress is involved in a variety of diseases. Prospective studies investigating the relationship between oxidative stress biomarkers and the status and development of colorectal cancer (CRC) are scarce; previous studies have failed to establish a relationship between the serum total oxidant...
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| Veröffentlicht in: | PloS one 2017-01, Vol.12 (1), p.e0170003-e0170003 |
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| description | Oxidative stress is involved in a variety of diseases. Prospective studies investigating the relationship between oxidative stress biomarkers and the status and development of colorectal cancer (CRC) are scarce; previous studies have failed to establish a relationship between the serum total oxidant/antioxidant status and CRC. Therefore, we compared the total serum oxidant/antioxidant levels of CRC patients and healthy subjects, and analyzed their clinical significance in the CRC. Fasting blood samples from 132 CRC patients and 64 healthy subjects were collected. Oxidative stress parameters, including total oxidant status (TOS) and total antioxidant status (TAS), were measured, and the oxidative stress index (OSI) was calculated. The TOS and OSI levels increased significantly (P |
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Prospective studies investigating the relationship between oxidative stress biomarkers and the status and development of colorectal cancer (CRC) are scarce; previous studies have failed to establish a relationship between the serum total oxidant/antioxidant status and CRC. Therefore, we compared the total serum oxidant/antioxidant levels of CRC patients and healthy subjects, and analyzed their clinical significance in the CRC. Fasting blood samples from 132 CRC patients and 64 healthy subjects were collected. Oxidative stress parameters, including total oxidant status (TOS) and total antioxidant status (TAS), were measured, and the oxidative stress index (OSI) was calculated. The TOS and OSI levels increased significantly (P<0.001) and the TAS level significantly decreased (P<0.001) in the CRC group compared to those in the healthy control group. Oxidative stress parameters differed significantly depending on the patient's smoking and drinking status (P<0.05). The preoperative and postoperative levels of TOS, TAS, and OSI did not differ significantly between primary sites (colon/rectum) and clinical stages (P>0.05).However, the levels of TOS, TAS, and OSI were significantly different between patients with no metastasis and those with metastases to two organs (P<0.05) Finally, the parameters are affected by smoking and drinking, and subsequent research should be conducted excluding the relevant influencing factors.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0170003</identifier><identifier>PMID: 28103261</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Alcohol ; Alcohol Drinking - blood ; Alcohol Drinking - metabolism ; Antioxidants ; Antioxidants (Nutrients) ; Antioxidants - metabolism ; Bioindicators ; Biology and Life Sciences ; Biomarkers ; Cancer ; Carcinogens ; Care and treatment ; Case-Control Studies ; Cell growth ; Chemotherapy ; Cholecystectomy ; Colon ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - blood ; Colorectal Neoplasms - metabolism ; Comparative analysis ; Development and progression ; Disease ; DNA damage ; Dosage and administration ; Female ; Health aspects ; Hospitals ; Humans ; Laboratories ; Laparoscopy ; Lipid peroxidation ; Male ; Mathematical analysis ; Medicine and Health Sciences ; Metastases ; Metastasis ; Middle Aged ; Mortality ; Mutation ; Oncology ; Organs ; Oxidants - blood ; Oxidation ; Oxidative Stress ; Pathogenesis ; Patient outcomes ; Patients ; Radiation therapy ; Rectum ; Smoking ; Smoking - blood ; Smoking - metabolism ; Studies ; Surgery ; Tumors</subject><ispartof>PloS one, 2017-01, Vol.12 (1), p.e0170003-e0170003</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Wu et al 2017 Wu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-fdbef4da99c5036dc699ff421d187e1b5e6617d7336eb7f371501349f3a0c8083</citedby><cites>FETCH-LOGICAL-c692t-fdbef4da99c5036dc699ff421d187e1b5e6617d7336eb7f371501349f3a0c8083</cites><orcidid>0000-0001-6348-0636</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245835/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245835/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28103261$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Khodarahmi, Reza</contributor><creatorcontrib>Wu, Rong</creatorcontrib><creatorcontrib>Feng, Jiafu</creatorcontrib><creatorcontrib>Yang, Yuwei</creatorcontrib><creatorcontrib>Dai, Chunmei</creatorcontrib><creatorcontrib>Lu, Anyang</creatorcontrib><creatorcontrib>Li, Jie</creatorcontrib><creatorcontrib>Liao, Yao</creatorcontrib><creatorcontrib>Xiang, Miao</creatorcontrib><creatorcontrib>Huang, Qingmei</creatorcontrib><creatorcontrib>Wang, Dong</creatorcontrib><creatorcontrib>Du, Xiao-Bo</creatorcontrib><title>Significance of Serum Total Oxidant/Antioxidant Status in Patients with Colorectal Cancer</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Oxidative stress is involved in a variety of diseases. Prospective studies investigating the relationship between oxidative stress biomarkers and the status and development of colorectal cancer (CRC) are scarce; previous studies have failed to establish a relationship between the serum total oxidant/antioxidant status and CRC. Therefore, we compared the total serum oxidant/antioxidant levels of CRC patients and healthy subjects, and analyzed their clinical significance in the CRC. Fasting blood samples from 132 CRC patients and 64 healthy subjects were collected. Oxidative stress parameters, including total oxidant status (TOS) and total antioxidant status (TAS), were measured, and the oxidative stress index (OSI) was calculated. The TOS and OSI levels increased significantly (P<0.001) and the TAS level significantly decreased (P<0.001) in the CRC group compared to those in the healthy control group. Oxidative stress parameters differed significantly depending on the patient's smoking and drinking status (P<0.05). The preoperative and postoperative levels of TOS, TAS, and OSI did not differ significantly between primary sites (colon/rectum) and clinical stages (P>0.05).However, the levels of TOS, TAS, and OSI were significantly different between patients with no metastasis and those with metastases to two organs (P<0.05) Finally, the parameters are affected by smoking and drinking, and subsequent research should be conducted excluding the relevant influencing factors.</description><subject>Age</subject><subject>Alcohol</subject><subject>Alcohol Drinking - blood</subject><subject>Alcohol Drinking - metabolism</subject><subject>Antioxidants</subject><subject>Antioxidants (Nutrients)</subject><subject>Antioxidants - metabolism</subject><subject>Bioindicators</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Cancer</subject><subject>Carcinogens</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Cell growth</subject><subject>Chemotherapy</subject><subject>Cholecystectomy</subject><subject>Colon</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - blood</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Comparative analysis</subject><subject>Development and progression</subject><subject>Disease</subject><subject>DNA damage</subject><subject>Dosage and administration</subject><subject>Female</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Laparoscopy</subject><subject>Lipid peroxidation</subject><subject>Male</subject><subject>Mathematical analysis</subject><subject>Medicine and Health Sciences</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Mutation</subject><subject>Oncology</subject><subject>Organs</subject><subject>Oxidants - blood</subject><subject>Oxidation</subject><subject>Oxidative Stress</subject><subject>Pathogenesis</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Radiation therapy</subject><subject>Rectum</subject><subject>Smoking</subject><subject>Smoking - 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Prospective studies investigating the relationship between oxidative stress biomarkers and the status and development of colorectal cancer (CRC) are scarce; previous studies have failed to establish a relationship between the serum total oxidant/antioxidant status and CRC. Therefore, we compared the total serum oxidant/antioxidant levels of CRC patients and healthy subjects, and analyzed their clinical significance in the CRC. Fasting blood samples from 132 CRC patients and 64 healthy subjects were collected. Oxidative stress parameters, including total oxidant status (TOS) and total antioxidant status (TAS), were measured, and the oxidative stress index (OSI) was calculated. The TOS and OSI levels increased significantly (P<0.001) and the TAS level significantly decreased (P<0.001) in the CRC group compared to those in the healthy control group. Oxidative stress parameters differed significantly depending on the patient's smoking and drinking status (P<0.05). The preoperative and postoperative levels of TOS, TAS, and OSI did not differ significantly between primary sites (colon/rectum) and clinical stages (P>0.05).However, the levels of TOS, TAS, and OSI were significantly different between patients with no metastasis and those with metastases to two organs (P<0.05) Finally, the parameters are affected by smoking and drinking, and subsequent research should be conducted excluding the relevant influencing factors.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28103261</pmid><doi>10.1371/journal.pone.0170003</doi><orcidid>https://orcid.org/0000-0001-6348-0636</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-01, Vol.12 (1), p.e0170003-e0170003 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Alcohol Alcohol Drinking - blood Alcohol Drinking - metabolism Antioxidants Antioxidants (Nutrients) Antioxidants - metabolism Bioindicators Biology and Life Sciences Biomarkers Cancer Carcinogens Care and treatment Case-Control Studies Cell growth Chemotherapy Cholecystectomy Colon Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - blood Colorectal Neoplasms - metabolism Comparative analysis Development and progression Disease DNA damage Dosage and administration Female Health aspects Hospitals Humans Laboratories Laparoscopy Lipid peroxidation Male Mathematical analysis Medicine and Health Sciences Metastases Metastasis Middle Aged Mortality Mutation Oncology Organs Oxidants - blood Oxidation Oxidative Stress Pathogenesis Patient outcomes Patients Radiation therapy Rectum Smoking Smoking - blood Smoking - metabolism Studies Surgery Tumors |
| title | Significance of Serum Total Oxidant/Antioxidant Status in Patients with Colorectal Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T22%3A55%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Significance%20of%20Serum%20Total%20Oxidant/Antioxidant%20Status%20in%20Patients%20with%20Colorectal%20Cancer&rft.jtitle=PloS%20one&rft.au=Wu,%20Rong&rft.date=2017-01-19&rft.volume=12&rft.issue=1&rft.spage=e0170003&rft.epage=e0170003&rft.pages=e0170003-e0170003&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0170003&rft_dat=%3Cgale_plos_%3EA478133265%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1860107908&rft_id=info:pmid/28103261&rft_galeid=A478133265&rft_doaj_id=oai_doaj_org_article_ecb549902d974240a0e42f76b1295568&rfr_iscdi=true |