A New Statistical Approach to Characterize Chemical-Elicited Behavioral Effects in High-Throughput Studies Using Zebrafish

Zebrafish have become an important alternative model for characterizing chemical bioactivity, partly due to the efficiency at which systematic, high-dimensional data can be generated. However, these new data present analytical challenges associated with scale and diversity. We developed a novel, rob...

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Veröffentlicht in:	PloS one 2017-01, Vol.12 (1), p.e0169408
Hauptverfasser:	Zhang, Guozhu, Truong, Lisa, Tanguay, Robert L, Reif, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Automation Behavior Biocompatibility Bioinformatics Biological activity Biology and Life Sciences Biometry - methods Chemicals Coefficient of variation Danio rerio Data processing Embryos Extreme values Fertilization Genomes High-throughput screening High-Throughput Screening Assays - methods Laboratories Light effects Mathematical analysis Mathematical models Medicine and Health Sciences Models, Statistical Multivariate analysis Neurotoxicity Physical Sciences Physiological aspects R&D Research & development Research and Analysis Methods Statistical methods Statistical models Studies Toxicity Toxicology Variance analysis Zebrafish
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