Intracranial Injection of Dengue Virus Induces Interferon Stimulated Genes and CD8+ T Cell Infiltration by Sphingosine Kinase 1 Independent Pathways

We have previously reported that the absence of sphingosine kinase 1 (SK1) affects both dengue virus (DENV) infection and innate immune responses in vitro. Here we aimed to define SK1-dependancy of DENV-induced disease and the associated innate responses in vivo. The lack of a reliable mouse model w...

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Veröffentlicht in:	PloS one 2017-01, Vol.12 (1), p.e0169814
Hauptverfasser:	Al-Shujairi, Wisam H, Clarke, Jennifer N, Davies, Lorena T, Alsharifi, Mohammed, Pitson, Stuart M, Carr, Jillian M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - pharmacology Biology Biology and Life Sciences Body weight Body weight loss Brain Brain research CD4 antigen CD4-Positive T-Lymphocytes - immunology CD8 antigen Chemokines Cloning CXCL10 protein Dengue Dengue - drug therapy Dengue - immunology Dengue - virology Dengue fever Dengue Virus - drug effects Dengue Virus - immunology Encephalitis Flaviviridae Gene expression Gene Expression Regulation - drug effects Immune response Immunity, Innate - immunology Infections Infectious diseases Infiltration Injection Innate immunity Interferon Interferon regulatory factor 7 Interferon-beta - pharmacology Kinases Lymphocytes Lymphocytes T Medicine and Health Sciences Mice Mice, Inbred C57BL Mice, Knockout mRNA Pathology Phosphates Phosphotransferases (Alcohol Group Acceptor) - physiology Research and Analysis Methods Ribonucleic acid RNA Rodents Sphingosine 1-phosphate Sphingosine kinase Tropical diseases Vector-borne diseases Viral diseases Viral infections Virus Replication Viruses Weight loss West Nile virus β-Interferon
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