Relationship between Clinical Parameters and Brain Structure in Sporadic Amyotrophic Lateral Sclerosis Patients According to Onset Type: A Voxel-Based Morphometric Study

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing, phenotypically heterogeneous neurodegenerative disease affecting mainly the motor neuron system. The present voxel-based morphometry (VBM) study investigated whether patterns of brain atrophy differ among sporadic ALS subtypes. Sporadic A...

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Veröffentlicht in:	PloS one 2017-01, Vol.12 (1), p.e0168424-e0168424
Hauptverfasser:	Kim, Hee-Jin, de Leon, Mony, Wang, Xiuyuan, Kim, Hyun Young, Lee, Young-Jun, Kim, Yeon-Ha, Kim, Seung Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Age of Onset Alzheimer's disease Alzheimers disease Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - pathology Analysis Atrophy Biology and Life Sciences Brain Brain - pathology Brain research Case-Control Studies Cognition Cortex Cortex (motor) Cortex (temporal) Dementia Development and progression Female Humans Image Processing, Computer-Assisted Laboratories Magnetic Resonance Imaging Male Medical imaging Medical prognosis Medicine Medicine and Health Sciences Middle Aged Morphometrics (Biology) Morphometry Motor neurons Multiple regression analysis Neural networks Neuroimaging Neurology Neurosciences NMR Nuclear magnetic resonance Ostomy Patients Regression analysis Research and Analysis Methods Risk factors Studies Subgroups Substantia grisea Superior temporal gyrus Systematic review Temporal cortex Temporal gyrus
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