Investigation of Inclusion Complex of Patchouli Alcohol with β-Cyclodextrin
The objective of this study was to improve the stability and water-solubility of patchouli alcohol by complexing with β-cyclodextrin (β-CD). The interactions between patchouli alcohol and β-CD were characterized by differential scanning calorimetry (DSC), Fourier transformation-infrared (FT-IR) spec...
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| Veröffentlicht in: | PloS one 2017-01, Vol.12 (1), p.e0169578-e0169578 |
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| creator | Xu, Fangfang Yang, Qiuxia Wu, Lilan Qi, Rui Wu, Yunshan Li, Yucui Tang, Lipeng Guo, De-An Liu, Bo |
| description | The objective of this study was to improve the stability and water-solubility of patchouli alcohol by complexing with β-cyclodextrin (β-CD). The interactions between patchouli alcohol and β-CD were characterized by differential scanning calorimetry (DSC), Fourier transformation-infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), and Scanning electron microscope (SEM), respectively. According to molecular modeling method, the enthalpy formation of host-guest illustrated the predominant configuration and the lowest value ΔbGo was -10.8174±1.9235 kcal/mol, suggesting the complex could reduce the energy of the system. The characterization analysis confirmed the formation of PA-CD inclusion complex, and the results indicated the advantage of the inclusion complex in stability and dissolution rates. These results identified PA-CD inclusion complex an effective way for the storage of PA, and better inclusion method still needed to be studied. |
| doi_str_mv | 10.1371/journal.pone.0169578 |
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The interactions between patchouli alcohol and β-CD were characterized by differential scanning calorimetry (DSC), Fourier transformation-infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), and Scanning electron microscope (SEM), respectively. According to molecular modeling method, the enthalpy formation of host-guest illustrated the predominant configuration and the lowest value ΔbGo was -10.8174±1.9235 kcal/mol, suggesting the complex could reduce the energy of the system. The characterization analysis confirmed the formation of PA-CD inclusion complex, and the results indicated the advantage of the inclusion complex in stability and dissolution rates. These results identified PA-CD inclusion complex an effective way for the storage of PA, and better inclusion method still needed to be studied.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0169578</identifier><identifier>PMID: 28095424</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Alcohol ; Alcohols ; beta-Cyclodextrins - chemistry ; beta-Cyclodextrins - metabolism ; Bioavailability ; Calorimetry ; Calorimetry, Differential Scanning ; Chemistry ; Chinese medicine ; Cyclodextrins ; Differential scanning calorimetry ; Drug delivery systems ; Earth Sciences ; Engineering and Technology ; Enthalpy ; Fourier transforms ; Inclusion Bodies - chemistry ; Inclusion Bodies - metabolism ; Infrared spectroscopy ; Models, Molecular ; Molecular modelling ; Pharmaceuticals ; Physical Sciences ; Pogostemon cablin ; Research and Analysis Methods ; Scanning electron microscopy ; Science ; Sesquiterpenes - chemistry ; Sesquiterpenes - metabolism ; Solubility ; Spectroscopy ; Spectroscopy, Fourier Transform Infrared ; Stability ; Thermodynamics ; X ray powder diffraction ; X-Ray Diffraction ; β-Cyclodextrin</subject><ispartof>PloS one, 2017-01, Vol.12 (1), p.e0169578-e0169578</ispartof><rights>2017 Xu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Xu et al 2017 Xu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-a04f920b44a2ee28ad98661c8cbb5b9a5f19a9405af6579a7967a8bc5d6cb1503</citedby><cites>FETCH-LOGICAL-c526t-a04f920b44a2ee28ad98661c8cbb5b9a5f19a9405af6579a7967a8bc5d6cb1503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240955/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240955/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28095424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Zheng, Jie</contributor><creatorcontrib>Xu, Fangfang</creatorcontrib><creatorcontrib>Yang, Qiuxia</creatorcontrib><creatorcontrib>Wu, Lilan</creatorcontrib><creatorcontrib>Qi, Rui</creatorcontrib><creatorcontrib>Wu, Yunshan</creatorcontrib><creatorcontrib>Li, Yucui</creatorcontrib><creatorcontrib>Tang, Lipeng</creatorcontrib><creatorcontrib>Guo, De-An</creatorcontrib><creatorcontrib>Liu, Bo</creatorcontrib><title>Investigation of Inclusion Complex of Patchouli Alcohol with β-Cyclodextrin</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The objective of this study was to improve the stability and water-solubility of patchouli alcohol by complexing with β-cyclodextrin (β-CD). The interactions between patchouli alcohol and β-CD were characterized by differential scanning calorimetry (DSC), Fourier transformation-infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), and Scanning electron microscope (SEM), respectively. According to molecular modeling method, the enthalpy formation of host-guest illustrated the predominant configuration and the lowest value ΔbGo was -10.8174±1.9235 kcal/mol, suggesting the complex could reduce the energy of the system. The characterization analysis confirmed the formation of PA-CD inclusion complex, and the results indicated the advantage of the inclusion complex in stability and dissolution rates. These results identified PA-CD inclusion complex an effective way for the storage of PA, and better inclusion method still needed to be studied.</description><subject>Alcohol</subject><subject>Alcohols</subject><subject>beta-Cyclodextrins - chemistry</subject><subject>beta-Cyclodextrins - metabolism</subject><subject>Bioavailability</subject><subject>Calorimetry</subject><subject>Calorimetry, Differential Scanning</subject><subject>Chemistry</subject><subject>Chinese medicine</subject><subject>Cyclodextrins</subject><subject>Differential scanning calorimetry</subject><subject>Drug delivery systems</subject><subject>Earth Sciences</subject><subject>Engineering and Technology</subject><subject>Enthalpy</subject><subject>Fourier transforms</subject><subject>Inclusion Bodies - chemistry</subject><subject>Inclusion Bodies - metabolism</subject><subject>Infrared spectroscopy</subject><subject>Models, Molecular</subject><subject>Molecular modelling</subject><subject>Pharmaceuticals</subject><subject>Physical Sciences</subject><subject>Pogostemon cablin</subject><subject>Research and Analysis Methods</subject><subject>Scanning electron microscopy</subject><subject>Science</subject><subject>Sesquiterpenes - chemistry</subject><subject>Sesquiterpenes - metabolism</subject><subject>Solubility</subject><subject>Spectroscopy</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Stability</subject><subject>Thermodynamics</subject><subject>X ray powder diffraction</subject><subject>X-Ray Diffraction</subject><subject>β-Cyclodextrin</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUstu1DAUjRCIlsIfIIjEhk2mtuNHvEGqRgVGGokuYG1dO86MRx57sJPS_lY_hG8iYdKqRaxsX5977rlHpyjeYrTAtcDnuzikAH5xiMEuEOaSieZZcYplTSpOUP380f2keJXzDiFWN5y_LE5IgySjhJ4W61W4trl3G-hdDGXsylUwfsjTYxn3B29vpuIV9GYbB-_KC2_iNvryl-u35e-7anlrfGztTZ9ceF286MBn-2Y-z4ofny-_L79W629fVsuLdWUY4X0FiHaSIE0pEGtJA60cZWHTGK2ZlsA6LEFSxKDjTEgQkgtotGEtNxozVJ8V74-8Bx-zmo3ICjdMUiqJqEfE6ohoI-zUIbk9pFsVwam_hZg2ClLvjLdKUGw17mqKjaBdI0YtxGrTasMNQ4KNXJ_maYPe29bY0CfwT0if_gS3VZt4rRiho80TwceZIMWfw-i22rtsrPcQbBwm3RwzgZHAI_TDP9D_b0ePKJNizsl2D2IwUlM47rvUFA41h2Nse_d4kYem-zTUfwBOWrk4</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Xu, Fangfang</creator><creator>Yang, Qiuxia</creator><creator>Wu, Lilan</creator><creator>Qi, Rui</creator><creator>Wu, Yunshan</creator><creator>Li, Yucui</creator><creator>Tang, Lipeng</creator><creator>Guo, De-An</creator><creator>Liu, Bo</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20170101</creationdate><title>Investigation of Inclusion Complex of Patchouli Alcohol with β-Cyclodextrin</title><author>Xu, Fangfang ; Yang, Qiuxia ; Wu, Lilan ; Qi, Rui ; Wu, Yunshan ; Li, Yucui ; Tang, Lipeng ; Guo, De-An ; Liu, Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-a04f920b44a2ee28ad98661c8cbb5b9a5f19a9405af6579a7967a8bc5d6cb1503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alcohol</topic><topic>Alcohols</topic><topic>beta-Cyclodextrins - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Fangfang</au><au>Yang, Qiuxia</au><au>Wu, Lilan</au><au>Qi, Rui</au><au>Wu, Yunshan</au><au>Li, Yucui</au><au>Tang, Lipeng</au><au>Guo, De-An</au><au>Liu, Bo</au><au>Zheng, Jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of Inclusion Complex of Patchouli Alcohol with β-Cyclodextrin</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>12</volume><issue>1</issue><spage>e0169578</spage><epage>e0169578</epage><pages>e0169578-e0169578</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The objective of this study was to improve the stability and water-solubility of patchouli alcohol by complexing with β-cyclodextrin (β-CD). The interactions between patchouli alcohol and β-CD were characterized by differential scanning calorimetry (DSC), Fourier transformation-infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), and Scanning electron microscope (SEM), respectively. According to molecular modeling method, the enthalpy formation of host-guest illustrated the predominant configuration and the lowest value ΔbGo was -10.8174±1.9235 kcal/mol, suggesting the complex could reduce the energy of the system. The characterization analysis confirmed the formation of PA-CD inclusion complex, and the results indicated the advantage of the inclusion complex in stability and dissolution rates. These results identified PA-CD inclusion complex an effective way for the storage of PA, and better inclusion method still needed to be studied.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28095424</pmid><doi>10.1371/journal.pone.0169578</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Alcohol Alcohols beta-Cyclodextrins - chemistry beta-Cyclodextrins - metabolism Bioavailability Calorimetry Calorimetry, Differential Scanning Chemistry Chinese medicine Cyclodextrins Differential scanning calorimetry Drug delivery systems Earth Sciences Engineering and Technology Enthalpy Fourier transforms Inclusion Bodies - chemistry Inclusion Bodies - metabolism Infrared spectroscopy Models, Molecular Molecular modelling Pharmaceuticals Physical Sciences Pogostemon cablin Research and Analysis Methods Scanning electron microscopy Science Sesquiterpenes - chemistry Sesquiterpenes - metabolism Solubility Spectroscopy Spectroscopy, Fourier Transform Infrared Stability Thermodynamics X ray powder diffraction X-Ray Diffraction β-Cyclodextrin |
| title | Investigation of Inclusion Complex of Patchouli Alcohol with β-Cyclodextrin |
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