The Gene Regulatory Network of Lens Induction Is Wired through Meis-Dependent Shadow Enhancers of Pax6

Lens induction is a classical developmental model allowing investigation of cell specification, spatiotemporal control of gene expression, as well as how transcription factors are integrated into highly complex gene regulatory networks (GRNs). Pax6 represents a key node in the gene regulatory networ...

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Veröffentlicht in:	PLoS genetics 2016-12, Vol.12 (12), p.e1006441-e1006441
Hauptverfasser:	Antosova, Barbora, Smolikova, Jana, Klimova, Lucie, Lachova, Jitka, Bendova, Michaela, Kozmikova, Iryna, Machon, Ondrej, Kozmik, Zbynek
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Biology Biology and Life Sciences Danio rerio Ectoderm - growth & development Ectoderm - pathology Enhancer Elements, Genetic - genetics Experiments Eye - growth & development Eye - metabolism Eye - pathology Gene expression Gene Expression Regulation, Developmental Gene Regulatory Networks - genetics Genetics Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Laboratories Lens, Crystalline - growth & development Lens, Crystalline - metabolism Lens, Crystalline - pathology Medicine and Health Sciences Mice Myeloid Ecotropic Viral Integration Site 1 Protein Neoplasm Proteins - genetics Neoplasm Proteins - metabolism PAX6 Transcription Factor - genetics PAX6 Transcription Factor - metabolism Research and Analysis Methods Rodents Transcription factors Zebrafish - genetics
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