Extensive Regulation of Diurnal Transcription and Metabolism by Glucocorticoids

Altered daily patterns of hormone action are suspected to contribute to metabolic disease. It is poorly understood how the adrenal glucocorticoid hormones contribute to the coordination of daily global patterns of transcription and metabolism. Here, we examined diurnal metabolite and transcriptome p...

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Veröffentlicht in:	PLoS genetics 2016-12, Vol.12 (12), p.e1006512
Hauptverfasser:	Weger, Benjamin D, Weger, Meltem, Görling, Benjamin, Schink, Andrea, Gobet, Cédric, Keime, Céline, Poschet, Gernot, Jost, Bernard, Krone, Nils, Hell, Rüdiger, Gachon, Frédéric, Luy, Burkhard, Dickmeis, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry, Molecular Biology Biology and Life Sciences Bioluminescence Circadian Clocks - genetics Circadian rhythm Circadian Rhythm - genetics Citric Acid - metabolism CLOCK Proteins - biosynthesis CLOCK Proteins - genetics Colleges & universities Danio rerio E-Box Elements - genetics Evacuations & rescues Funding Gene expression Gene Expression Regulation Glucocorticoids - biosynthesis Glucocorticoids - deficiency Glucocorticoids - genetics Health sciences High-Throughput Nucleotide Sequencing Hormones Hormones - genetics Hormones - metabolism Humans Life Sciences Magnetic Resonance Spectroscopy Metabolic Networks and Pathways - genetics Metabolism Metabolites Organic chemistry Physical Sciences Research and Analysis Methods Toxicology Transcription, Genetic Transcriptome - genetics Urea - metabolism Zebrafish
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