A Differentiation Transcription Factor Establishes Muscle-Specific Proteostasis in Caenorhabditis elegans

Safeguarding the proteome is central to the health of the cell. In multi-cellular organisms, the composition of the proteome, and by extension, protein-folding requirements, varies between cells. In agreement, chaperone network composition differs between tissues. Here, we ask how chaperone expressi...

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Veröffentlicht in:	PLoS genetics 2016-12, Vol.12 (12), p.e1006531-e1006531
Hauptverfasser:	Bar-Lavan, Yael, Shemesh, Netta, Dror, Shiran, Ofir, Rivka, Yeger-Lotem, Esti, Ben-Zvi, Anat
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals Binding Sites Bioinformatics Biology and Life Sciences Biotechnology Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Caenorhabditis elegans Proteins - biosynthesis Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cell Differentiation - genetics Colleges & universities DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Embryonic Development - genetics Embryos Experiments Funding Gene Expression Regulation, Developmental Genes Heat-Shock Proteins - biosynthesis Heat-Shock Proteins - genetics HSP40 Heat-Shock Proteins - genetics HSP40 Heat-Shock Proteins - metabolism HSP90 Heat-Shock Proteins - genetics HSP90 Heat-Shock Proteins - metabolism Immunoglobulins Life sciences Medicine and Health Sciences Molecular Chaperones - biosynthesis Molecular Chaperones - genetics Molecular Chaperones - metabolism Muscle Cells - metabolism Muscle Development - genetics Myogenic Regulatory Factors - genetics Myogenic Regulatory Factors - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Promoter Regions, Genetic Proteins Transcription factors Young adults
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