Serological Evidence of Contrasted Exposure to Arboviral Infections between Islands of the Union of Comoros (Indian Ocean)
A cross sectional serological survey of arboviral infections in humans was conducted on the three islands of the Union of Comoros, Indian Ocean, in order to test a previously suggested contrasted exposure of the three neighboring islands to arthropod-borne epidemics. Four hundred human sera were col...
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| creator | Dellagi, Koussay Salez, Nicolas Maquart, Marianne Larrieu, Sophie Yssouf, Amina Silaï, Rahamatou Leparc-Goffart, Isabelle Tortosa, Pablo de Lamballerie, Xavier |
| description | A cross sectional serological survey of arboviral infections in humans was conducted on the three islands of the Union of Comoros, Indian Ocean, in order to test a previously suggested contrasted exposure of the three neighboring islands to arthropod-borne epidemics. Four hundred human sera were collected on Ngazidja (Grande Comore), Mwali (Mohéli) and Ndzouani (Anjouan), and were tested by ELISA for IgM and/or IgG antibodies to Dengue (DENV), Chikungunya (CHIKV), Rift Valley fever (RVFV), West Nile (WNV), Tick borne encephalitis (TBEV) and Yellow fever (YFV) viruses and for neutralizing antibodies to DENV serotypes 1-4. Very few sera were positive for IgM antibodies to the tested viruses indicating that the sero-survey was performed during an inter epidemic phase for the investigated arbovirus infections, except for RVF which showed evidence of recent infections on all three islands. IgG reactivity with at least one arbovirus was observed in almost 85% of tested sera, with seropositivity rates increasing with age, indicative of an intense and long lasting exposure of the Comorian population to arboviral risk. Interestingly, the positivity rates for IgG antibodies to DENV and CHIKV were significantly higher on Ngazidja, confirming the previously suggested prominent exposure of this island to these arboviruses, while serological traces of WNV infection were detected most frequently on Mwali suggesting some transmission specificities associated with this island only. The study provides the first evidence for circulation of RVFV in human populations from the Union of Comoros and further suggests that the virus is currently circulating on the three islands in an inconspicuous manner. This study supports contrasted exposure of the islands of the Comoros archipelago to arboviral infections. The observation is discussed in terms of ecological factors that may affect the abundance and distribution of vector populations on the three islands as well as concurring anthropogenic factors that may impact arbovirus transmission in this diverse island ecosystem. |
| doi_str_mv | 10.1371/journal.pntd.0004840 |
| format | Article |
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Four hundred human sera were collected on Ngazidja (Grande Comore), Mwali (Mohéli) and Ndzouani (Anjouan), and were tested by ELISA for IgM and/or IgG antibodies to Dengue (DENV), Chikungunya (CHIKV), Rift Valley fever (RVFV), West Nile (WNV), Tick borne encephalitis (TBEV) and Yellow fever (YFV) viruses and for neutralizing antibodies to DENV serotypes 1-4. Very few sera were positive for IgM antibodies to the tested viruses indicating that the sero-survey was performed during an inter epidemic phase for the investigated arbovirus infections, except for RVF which showed evidence of recent infections on all three islands. IgG reactivity with at least one arbovirus was observed in almost 85% of tested sera, with seropositivity rates increasing with age, indicative of an intense and long lasting exposure of the Comorian population to arboviral risk. 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The observation is discussed in terms of ecological factors that may affect the abundance and distribution of vector populations on the three islands as well as concurring anthropogenic factors that may impact arbovirus transmission in this diverse island ecosystem.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0004840</identifier><identifier>PMID: 27977670</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Anthropogenic factors ; Antibodies, Neutralizing - blood ; Antibodies, Viral - blood ; Arbovirus diseases ; Arbovirus Infections - epidemiology ; Arbovirus Infections - transmission ; Arbovirus Infections - virology ; Arboviruses - immunology ; Archipelagoes ; Biology and life sciences ; Chikungunya Fever - epidemiology ; Chikungunya Fever - immunology ; Chikungunya Fever - transmission ; Chikungunya Fever - virology ; Comoros - epidemiology ; Cross-Sectional Studies ; Dengue - epidemiology ; Dengue - immunology ; Dengue - transmission ; Dengue - virology ; Ecosystems ; Emerging diseases ; Epidemics ; Epidemiology ; Exposure ; Female ; Haplotypes ; Human health and pathology ; Human populations ; Humans ; Immunoglobulin G - blood ; Immunoglobulin M - blood ; Immunoglobulins ; Infections ; Infectious diseases ; Islands ; Life Sciences ; Male ; Medicine and health sciences ; Middle Aged ; Mosquito Vectors - virology ; People and Places ; Public health ; Research and Analysis Methods ; Rift Valley Fever - epidemiology ; Rift Valley Fever - immunology ; Rift Valley Fever - transmission ; Rift Valley Fever - virology ; Risk factors ; Santé publique et épidémiologie ; Seroepidemiologic Studies ; Serogroup ; Studies ; Tropical diseases ; Vector-borne diseases ; Yellow Fever - epidemiology ; Yellow Fever - immunology ; Yellow Fever - transmission ; Yellow Fever - virology ; Young Adult</subject><ispartof>PLoS neglected tropical diseases, 2016-12, Vol.10 (12), p.e0004840-e0004840</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Dellagi K, Salez N, Maquart M, Larrieu S, Yssouf A, Silaï R, et al. (2016) Serological Evidence of Contrasted Exposure to Arboviral Infections between Islands of the Union of Comoros (Indian Ocean). PLoS Negl Trop Dis 10(12): e0004840. doi:10.1371/journal.pntd.0004840</rights><rights>Attribution</rights><rights>2016 Dellagi et al 2016 Dellagi et al</rights><rights>2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Dellagi K, Salez N, Maquart M, Larrieu S, Yssouf A, Silaï R, et al. (2016) Serological Evidence of Contrasted Exposure to Arboviral Infections between Islands of the Union of Comoros (Indian Ocean). PLoS Negl Trop Dis 10(12): e0004840. doi:10.1371/journal.pntd.0004840</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c658t-c96eb5220ee6ea6ee5edf3ef98bbf5dd9b8c667a0ae363f1c8baa7ae19f062f93</citedby><cites>FETCH-LOGICAL-c658t-c96eb5220ee6ea6ee5edf3ef98bbf5dd9b8c667a0ae363f1c8baa7ae19f062f93</cites><orcidid>0000-0002-7928-7264 ; 0000-0001-7895-2720 ; 0000-0001-7920-7490</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157944/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157944/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27977670$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01423540$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Dellagi, Koussay</creatorcontrib><creatorcontrib>Salez, Nicolas</creatorcontrib><creatorcontrib>Maquart, Marianne</creatorcontrib><creatorcontrib>Larrieu, Sophie</creatorcontrib><creatorcontrib>Yssouf, Amina</creatorcontrib><creatorcontrib>Silaï, Rahamatou</creatorcontrib><creatorcontrib>Leparc-Goffart, Isabelle</creatorcontrib><creatorcontrib>Tortosa, Pablo</creatorcontrib><creatorcontrib>de Lamballerie, Xavier</creatorcontrib><title>Serological Evidence of Contrasted Exposure to Arboviral Infections between Islands of the Union of Comoros (Indian Ocean)</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>A cross sectional serological survey of arboviral infections in humans was conducted on the three islands of the Union of Comoros, Indian Ocean, in order to test a previously suggested contrasted exposure of the three neighboring islands to arthropod-borne epidemics. Four hundred human sera were collected on Ngazidja (Grande Comore), Mwali (Mohéli) and Ndzouani (Anjouan), and were tested by ELISA for IgM and/or IgG antibodies to Dengue (DENV), Chikungunya (CHIKV), Rift Valley fever (RVFV), West Nile (WNV), Tick borne encephalitis (TBEV) and Yellow fever (YFV) viruses and for neutralizing antibodies to DENV serotypes 1-4. Very few sera were positive for IgM antibodies to the tested viruses indicating that the sero-survey was performed during an inter epidemic phase for the investigated arbovirus infections, except for RVF which showed evidence of recent infections on all three islands. IgG reactivity with at least one arbovirus was observed in almost 85% of tested sera, with seropositivity rates increasing with age, indicative of an intense and long lasting exposure of the Comorian population to arboviral risk. Interestingly, the positivity rates for IgG antibodies to DENV and CHIKV were significantly higher on Ngazidja, confirming the previously suggested prominent exposure of this island to these arboviruses, while serological traces of WNV infection were detected most frequently on Mwali suggesting some transmission specificities associated with this island only. The study provides the first evidence for circulation of RVFV in human populations from the Union of Comoros and further suggests that the virus is currently circulating on the three islands in an inconspicuous manner. This study supports contrasted exposure of the islands of the Comoros archipelago to arboviral infections. The observation is discussed in terms of ecological factors that may affect the abundance and distribution of vector populations on the three islands as well as concurring anthropogenic factors that may impact arbovirus transmission in this diverse island ecosystem.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anthropogenic factors</subject><subject>Antibodies, Neutralizing - blood</subject><subject>Antibodies, Viral - blood</subject><subject>Arbovirus diseases</subject><subject>Arbovirus Infections - epidemiology</subject><subject>Arbovirus Infections - transmission</subject><subject>Arbovirus Infections - virology</subject><subject>Arboviruses - immunology</subject><subject>Archipelagoes</subject><subject>Biology and life sciences</subject><subject>Chikungunya Fever - epidemiology</subject><subject>Chikungunya Fever - immunology</subject><subject>Chikungunya Fever - transmission</subject><subject>Chikungunya Fever - virology</subject><subject>Comoros - epidemiology</subject><subject>Cross-Sectional Studies</subject><subject>Dengue - 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blood</topic><topic>Immunoglobulin M - blood</topic><topic>Immunoglobulins</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Islands</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Medicine and health sciences</topic><topic>Middle Aged</topic><topic>Mosquito Vectors - virology</topic><topic>People and Places</topic><topic>Public health</topic><topic>Research and Analysis Methods</topic><topic>Rift Valley Fever - epidemiology</topic><topic>Rift Valley Fever - immunology</topic><topic>Rift Valley Fever - transmission</topic><topic>Rift Valley Fever - virology</topic><topic>Risk factors</topic><topic>Santé publique et épidémiologie</topic><topic>Seroepidemiologic Studies</topic><topic>Serogroup</topic><topic>Studies</topic><topic>Tropical diseases</topic><topic>Vector-borne diseases</topic><topic>Yellow Fever - epidemiology</topic><topic>Yellow Fever - immunology</topic><topic>Yellow Fever - transmission</topic><topic>Yellow Fever - virology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dellagi, Koussay</creatorcontrib><creatorcontrib>Salez, Nicolas</creatorcontrib><creatorcontrib>Maquart, Marianne</creatorcontrib><creatorcontrib>Larrieu, Sophie</creatorcontrib><creatorcontrib>Yssouf, Amina</creatorcontrib><creatorcontrib>Silaï, Rahamatou</creatorcontrib><creatorcontrib>Leparc-Goffart, Isabelle</creatorcontrib><creatorcontrib>Tortosa, Pablo</creatorcontrib><creatorcontrib>de Lamballerie, Xavier</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS neglected tropical diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dellagi, Koussay</au><au>Salez, Nicolas</au><au>Maquart, Marianne</au><au>Larrieu, Sophie</au><au>Yssouf, Amina</au><au>Silaï, Rahamatou</au><au>Leparc-Goffart, Isabelle</au><au>Tortosa, Pablo</au><au>de Lamballerie, Xavier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serological Evidence of Contrasted Exposure to Arboviral Infections between Islands of the Union of Comoros (Indian Ocean)</atitle><jtitle>PLoS neglected tropical diseases</jtitle><addtitle>PLoS Negl Trop Dis</addtitle><date>2016-12-15</date><risdate>2016</risdate><volume>10</volume><issue>12</issue><spage>e0004840</spage><epage>e0004840</epage><pages>e0004840-e0004840</pages><issn>1935-2735</issn><issn>1935-2727</issn><eissn>1935-2735</eissn><abstract>A cross sectional serological survey of arboviral infections in humans was conducted on the three islands of the Union of Comoros, Indian Ocean, in order to test a previously suggested contrasted exposure of the three neighboring islands to arthropod-borne epidemics. Four hundred human sera were collected on Ngazidja (Grande Comore), Mwali (Mohéli) and Ndzouani (Anjouan), and were tested by ELISA for IgM and/or IgG antibodies to Dengue (DENV), Chikungunya (CHIKV), Rift Valley fever (RVFV), West Nile (WNV), Tick borne encephalitis (TBEV) and Yellow fever (YFV) viruses and for neutralizing antibodies to DENV serotypes 1-4. Very few sera were positive for IgM antibodies to the tested viruses indicating that the sero-survey was performed during an inter epidemic phase for the investigated arbovirus infections, except for RVF which showed evidence of recent infections on all three islands. IgG reactivity with at least one arbovirus was observed in almost 85% of tested sera, with seropositivity rates increasing with age, indicative of an intense and long lasting exposure of the Comorian population to arboviral risk. Interestingly, the positivity rates for IgG antibodies to DENV and CHIKV were significantly higher on Ngazidja, confirming the previously suggested prominent exposure of this island to these arboviruses, while serological traces of WNV infection were detected most frequently on Mwali suggesting some transmission specificities associated with this island only. The study provides the first evidence for circulation of RVFV in human populations from the Union of Comoros and further suggests that the virus is currently circulating on the three islands in an inconspicuous manner. This study supports contrasted exposure of the islands of the Comoros archipelago to arboviral infections. The observation is discussed in terms of ecological factors that may affect the abundance and distribution of vector populations on the three islands as well as concurring anthropogenic factors that may impact arbovirus transmission in this diverse island ecosystem.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27977670</pmid><doi>10.1371/journal.pntd.0004840</doi><orcidid>https://orcid.org/0000-0002-7928-7264</orcidid><orcidid>https://orcid.org/0000-0001-7895-2720</orcidid><orcidid>https://orcid.org/0000-0001-7920-7490</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1935-2735 |
| ispartof | PLoS neglected tropical diseases, 2016-12, Vol.10 (12), p.e0004840-e0004840 |
| issn | 1935-2735 1935-2727 1935-2735 |
| language | eng |
| recordid | cdi_plos_journals_1858864618 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Adolescent Adult Anthropogenic factors Antibodies, Neutralizing - blood Antibodies, Viral - blood Arbovirus diseases Arbovirus Infections - epidemiology Arbovirus Infections - transmission Arbovirus Infections - virology Arboviruses - immunology Archipelagoes Biology and life sciences Chikungunya Fever - epidemiology Chikungunya Fever - immunology Chikungunya Fever - transmission Chikungunya Fever - virology Comoros - epidemiology Cross-Sectional Studies Dengue - epidemiology Dengue - immunology Dengue - transmission Dengue - virology Ecosystems Emerging diseases Epidemics Epidemiology Exposure Female Haplotypes Human health and pathology Human populations Humans Immunoglobulin G - blood Immunoglobulin M - blood Immunoglobulins Infections Infectious diseases Islands Life Sciences Male Medicine and health sciences Middle Aged Mosquito Vectors - virology People and Places Public health Research and Analysis Methods Rift Valley Fever - epidemiology Rift Valley Fever - immunology Rift Valley Fever - transmission Rift Valley Fever - virology Risk factors Santé publique et épidémiologie Seroepidemiologic Studies Serogroup Studies Tropical diseases Vector-borne diseases Yellow Fever - epidemiology Yellow Fever - immunology Yellow Fever - transmission Yellow Fever - virology Young Adult |
| title | Serological Evidence of Contrasted Exposure to Arboviral Infections between Islands of the Union of Comoros (Indian Ocean) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T03%3A04%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serological%20Evidence%20of%20Contrasted%20Exposure%20to%20Arboviral%20Infections%20between%20Islands%20of%20the%20Union%20of%20Comoros%20(Indian%20Ocean)&rft.jtitle=PLoS%20neglected%20tropical%20diseases&rft.au=Dellagi,%20Koussay&rft.date=2016-12-15&rft.volume=10&rft.issue=12&rft.spage=e0004840&rft.epage=e0004840&rft.pages=e0004840-e0004840&rft.issn=1935-2735&rft.eissn=1935-2735&rft_id=info:doi/10.1371/journal.pntd.0004840&rft_dat=%3Cgale_plos_%3EA478614787%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1858864618&rft_id=info:pmid/27977670&rft_galeid=A478614787&rft_doaj_id=oai_doaj_org_article_55dcbf8716de4568ab7bce7f2885becc&rfr_iscdi=true |