25-Hydroxivitamin D Serum Concentration, Not Free and Bioavailable Vitamin D, Is Associated with Disease Activity in Systemic Lupus Erythematosus Patients
We aim to evaluate the prevalence of vitamin D deficiency in patients with systemic lupus erythematosus (SLE) and investigate the association between total, free and bioavailable vitamin D serum concentrations and disease activity. Patients with SLE (ACR 1997) consecutively seen at UNIFESP's ou...
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| description | We aim to evaluate the prevalence of vitamin D deficiency in patients with systemic lupus erythematosus (SLE) and investigate the association between total, free and bioavailable vitamin D serum concentrations and disease activity. Patients with SLE (ACR 1997) consecutively seen at UNIFESP's outpatient's clinics had disease activity measured after clinical and laboratory evaluation using SLEDAI (Systemic Lupus Erythematosus Disease Activity Index). 25-hydroxyvitamin D (25(OH)D) serum concentrations measured by chemiluminescence and vitamin D binding protein (DBP) measured by ELISA were used to calculate free and bioavailable vitamin D. Healthy blood donors were used as controls. A total of 142 patients (71.4%) had 25(OH)D serum concentrations below 30 ng/mL. Total 25(OH)D serum concentration was associated with disease activity categorized in 5 continuous groups of SLEDAI. 25(OH)D serum concentrations were higher among patients with SLEDAI 1-5 and lower in those with severe activity (SLEDAI≥20) (p |
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Patients with SLE (ACR 1997) consecutively seen at UNIFESP's outpatient's clinics had disease activity measured after clinical and laboratory evaluation using SLEDAI (Systemic Lupus Erythematosus Disease Activity Index). 25-hydroxyvitamin D (25(OH)D) serum concentrations measured by chemiluminescence and vitamin D binding protein (DBP) measured by ELISA were used to calculate free and bioavailable vitamin D. Healthy blood donors were used as controls. A total of 142 patients (71.4%) had 25(OH)D serum concentrations below 30 ng/mL. Total 25(OH)D serum concentration was associated with disease activity categorized in 5 continuous groups of SLEDAI. 25(OH)D serum concentrations were higher among patients with SLEDAI 1-5 and lower in those with severe activity (SLEDAI≥20) (p <0.05). On the other hand, no statistically significant difference was observed for DBP, free and bioavailable vitamin D measurements in the disease activity subgroups evaluated. Vitamin D deficiency is highly prevalent among patients with SLE and was associated with higher disease activity. DBP serum level and calculation of free and bioavailable vitamin D were not associated with SLE disease activity.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0170323</identifier><identifier>PMID: 28085957</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>25-Hydroxyvitamin D ; Adult ; Autoimmune diseases ; Bioavailability ; Biology and Life Sciences ; Blood & organ donations ; Chemiluminescence ; Chronic conditions ; Complications and side effects ; Cross-Sectional Studies ; Development and progression ; Disease ; Endocrinology ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Lupus ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - metabolism ; Male ; Mathematical analysis ; Medicine and Health Sciences ; Metabolism ; Metabolites ; Middle Aged ; Osteoporosis ; Patients ; People and Places ; Physical sciences ; Prevalence ; Proteins ; Rheumatology ; Risk factors ; Statistical analysis ; Studies ; Subgroups ; Systemic lupus erythematosus ; Urine ; Vitamin D ; Vitamin D - blood ; Vitamin D deficiency ; Vitamin D Deficiency - complications ; Vitamin D Deficiency - epidemiology ; Vitamin D-Binding Protein ; Vitamin deficiency</subject><ispartof>PloS one, 2017-01, Vol.12 (1), p.e0170323-e0170323</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Eloi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Eloi et al 2017 Eloi et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-56dce065871edf1b3208bdc4ba9284ee1fcc232efc482e56f16b88fd91c7b18a3</citedby><cites>FETCH-LOGICAL-c725t-56dce065871edf1b3208bdc4ba9284ee1fcc232efc482e56f16b88fd91c7b18a3</cites><orcidid>0000-0001-9144-996X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234837/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234837/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28085957$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eloi, Marina</creatorcontrib><creatorcontrib>Horvath, Daniela Vargas</creatorcontrib><creatorcontrib>Ortega, João Carlos</creatorcontrib><creatorcontrib>Prado, Mônica Simon</creatorcontrib><creatorcontrib>Andrade, Luis Eduardo Coelho</creatorcontrib><creatorcontrib>Szejnfeld, Vera Lúcia</creatorcontrib><creatorcontrib>de Moura Castro, Charlles Heldan</creatorcontrib><title>25-Hydroxivitamin D Serum Concentration, Not Free and Bioavailable Vitamin D, Is Associated with Disease Activity in Systemic Lupus Erythematosus Patients</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>We aim to evaluate the prevalence of vitamin D deficiency in patients with systemic lupus erythematosus (SLE) and investigate the association between total, free and bioavailable vitamin D serum concentrations and disease activity. Patients with SLE (ACR 1997) consecutively seen at UNIFESP's outpatient's clinics had disease activity measured after clinical and laboratory evaluation using SLEDAI (Systemic Lupus Erythematosus Disease Activity Index). 25-hydroxyvitamin D (25(OH)D) serum concentrations measured by chemiluminescence and vitamin D binding protein (DBP) measured by ELISA were used to calculate free and bioavailable vitamin D. Healthy blood donors were used as controls. A total of 142 patients (71.4%) had 25(OH)D serum concentrations below 30 ng/mL. Total 25(OH)D serum concentration was associated with disease activity categorized in 5 continuous groups of SLEDAI. 25(OH)D serum concentrations were higher among patients with SLEDAI 1-5 and lower in those with severe activity (SLEDAI≥20) (p <0.05). On the other hand, no statistically significant difference was observed for DBP, free and bioavailable vitamin D measurements in the disease activity subgroups evaluated. Vitamin D deficiency is highly prevalent among patients with SLE and was associated with higher disease activity. DBP serum level and calculation of free and bioavailable vitamin D were not associated with SLE disease activity.</description><subject>25-Hydroxyvitamin D</subject><subject>Adult</subject><subject>Autoimmune diseases</subject><subject>Bioavailability</subject><subject>Biology and Life Sciences</subject><subject>Blood & organ donations</subject><subject>Chemiluminescence</subject><subject>Chronic conditions</subject><subject>Complications and side effects</subject><subject>Cross-Sectional Studies</subject><subject>Development and progression</subject><subject>Disease</subject><subject>Endocrinology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Humans</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - complications</subject><subject>Lupus Erythematosus, Systemic - metabolism</subject><subject>Male</subject><subject>Mathematical analysis</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Osteoporosis</subject><subject>Patients</subject><subject>People and Places</subject><subject>Physical sciences</subject><subject>Prevalence</subject><subject>Proteins</subject><subject>Rheumatology</subject><subject>Risk factors</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Subgroups</subject><subject>Systemic lupus erythematosus</subject><subject>Urine</subject><subject>Vitamin D</subject><subject>Vitamin D - blood</subject><subject>Vitamin D deficiency</subject><subject>Vitamin D Deficiency - complications</subject><subject>Vitamin D Deficiency - epidemiology</subject><subject>Vitamin D-Binding Protein</subject><subject>Vitamin deficiency</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYmPwDxBYmoRAWos_8uHcIJVuY5Uqhijs1nKck9ZTEhfbKetf4dfi0HZq0S6mXCR2nvc99vmIotcEDwnLyMdb09lW1sOlaWGISYYZZU-iY5IzOkgpZk_3vo-iF87dYpwwnqbPoyPKMU_yJDuO_tBkcLUurbnTK-1lo1t0jmZguwaNTaug9VZ6bdoz9NV4dGkBkGxL9FkbuZK6lkUN6GYnPEMTh0bOGaWlhxL91n6BzrUD6QCNlO9DrFEgZ2vnodEKTbtl59CFXfsFNNIbF1bfQsAQ172MnlWydvBq-z6Jfl5e_BhfDabXXybj0XSgMpr4QZKWCnCa8IxAWZGCUcyLUsWFzCmPAUilFGUUKhVzCklakbTgvCpzorKCcMlOorcb32VtnNim1QnCE07zjORJICYbojTyViytbqRdCyO1-Ldh7FxI67WqQTDAXFUsLSmncVEUnPEqk3GaqlAznGfB69M2Wlc0UG4yXB-YHv5p9ULMzUoklMWc9QbvtwbW_OrAedFop6CuZQum68-dcoZTmuePQUlCWM76K57-hz6ciC01l-Guuq1MOKLqTcUozrI4NCYlgRo-QIWn7Gse2rXSYf9A8OFAEBgPd34uO-fEZPb98ez1zSH7bo9dgKz9wpm66xvaHYLxBlTWOGehuq8HwaKftl02RD9tYjttQfZmv5b3ot14sb-zjiWi</recordid><startdate>20170113</startdate><enddate>20170113</enddate><creator>Eloi, Marina</creator><creator>Horvath, Daniela Vargas</creator><creator>Ortega, João Carlos</creator><creator>Prado, Mônica Simon</creator><creator>Andrade, Luis Eduardo Coelho</creator><creator>Szejnfeld, Vera Lúcia</creator><creator>de Moura Castro, Charlles Heldan</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-9144-996X</orcidid></search><sort><creationdate>20170113</creationdate><title>25-Hydroxivitamin D Serum Concentration, Not Free and Bioavailable Vitamin D, Is Associated with Disease Activity in Systemic Lupus Erythematosus Patients</title><author>Eloi, Marina ; Horvath, Daniela Vargas ; Ortega, João Carlos ; Prado, Mônica Simon ; Andrade, Luis Eduardo Coelho ; Szejnfeld, Vera Lúcia ; de Moura Castro, Charlles Heldan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c725t-56dce065871edf1b3208bdc4ba9284ee1fcc232efc482e56f16b88fd91c7b18a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>25-Hydroxyvitamin D</topic><topic>Adult</topic><topic>Autoimmune diseases</topic><topic>Bioavailability</topic><topic>Biology and Life Sciences</topic><topic>Blood & organ donations</topic><topic>Chemiluminescence</topic><topic>Chronic conditions</topic><topic>Complications and side effects</topic><topic>Cross-Sectional Studies</topic><topic>Development and progression</topic><topic>Disease</topic><topic>Endocrinology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Humans</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eloi, Marina</au><au>Horvath, Daniela Vargas</au><au>Ortega, João Carlos</au><au>Prado, Mônica Simon</au><au>Andrade, Luis Eduardo Coelho</au><au>Szejnfeld, Vera Lúcia</au><au>de Moura Castro, Charlles Heldan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>25-Hydroxivitamin D Serum Concentration, Not Free and Bioavailable Vitamin D, Is Associated with Disease Activity in Systemic Lupus Erythematosus Patients</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-01-13</date><risdate>2017</risdate><volume>12</volume><issue>1</issue><spage>e0170323</spage><epage>e0170323</epage><pages>e0170323-e0170323</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>We aim to evaluate the prevalence of vitamin D deficiency in patients with systemic lupus erythematosus (SLE) and investigate the association between total, free and bioavailable vitamin D serum concentrations and disease activity. Patients with SLE (ACR 1997) consecutively seen at UNIFESP's outpatient's clinics had disease activity measured after clinical and laboratory evaluation using SLEDAI (Systemic Lupus Erythematosus Disease Activity Index). 25-hydroxyvitamin D (25(OH)D) serum concentrations measured by chemiluminescence and vitamin D binding protein (DBP) measured by ELISA were used to calculate free and bioavailable vitamin D. Healthy blood donors were used as controls. A total of 142 patients (71.4%) had 25(OH)D serum concentrations below 30 ng/mL. Total 25(OH)D serum concentration was associated with disease activity categorized in 5 continuous groups of SLEDAI. 25(OH)D serum concentrations were higher among patients with SLEDAI 1-5 and lower in those with severe activity (SLEDAI≥20) (p <0.05). On the other hand, no statistically significant difference was observed for DBP, free and bioavailable vitamin D measurements in the disease activity subgroups evaluated. Vitamin D deficiency is highly prevalent among patients with SLE and was associated with higher disease activity. DBP serum level and calculation of free and bioavailable vitamin D were not associated with SLE disease activity.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28085957</pmid><doi>10.1371/journal.pone.0170323</doi><tpages>e0170323</tpages><orcidid>https://orcid.org/0000-0001-9144-996X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-01, Vol.12 (1), p.e0170323-e0170323 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1858297195 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | 25-Hydroxyvitamin D Adult Autoimmune diseases Bioavailability Biology and Life Sciences Blood & organ donations Chemiluminescence Chronic conditions Complications and side effects Cross-Sectional Studies Development and progression Disease Endocrinology Enzyme-Linked Immunosorbent Assay Female Humans Lupus Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - metabolism Male Mathematical analysis Medicine and Health Sciences Metabolism Metabolites Middle Aged Osteoporosis Patients People and Places Physical sciences Prevalence Proteins Rheumatology Risk factors Statistical analysis Studies Subgroups Systemic lupus erythematosus Urine Vitamin D Vitamin D - blood Vitamin D deficiency Vitamin D Deficiency - complications Vitamin D Deficiency - epidemiology Vitamin D-Binding Protein Vitamin deficiency |
| title | 25-Hydroxivitamin D Serum Concentration, Not Free and Bioavailable Vitamin D, Is Associated with Disease Activity in Systemic Lupus Erythematosus Patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T16%3A07%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=25-Hydroxivitamin%20D%20Serum%20Concentration,%20Not%20Free%20and%20Bioavailable%20Vitamin%20D,%20Is%20Associated%20with%20Disease%20Activity%20in%20Systemic%20Lupus%20Erythematosus%20Patients&rft.jtitle=PloS%20one&rft.au=Eloi,%20Marina&rft.date=2017-01-13&rft.volume=12&rft.issue=1&rft.spage=e0170323&rft.epage=e0170323&rft.pages=e0170323-e0170323&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0170323&rft_dat=%3Cgale_plos_%3EA477413721%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1858297195&rft_id=info:pmid/28085957&rft_galeid=A477413721&rft_doaj_id=oai_doaj_org_article_3e08cf36d2824bbb838f7a466c371097&rfr_iscdi=true |