Upregulated Expression of Transient Receptor Potential Cation Channel Subfamily V Receptors in Mucosae of Patients with Oral Squamous Cell Carcinoma and Patients with a History of Alcohol Consumption or Smoking

Transient receptor potential cation channel (subfamily V, members 1-4) (TRPV1-4) are expressed in skin and neurons and activated by external stimuli in normal mucosae of all oral cavity sites. The oral cavity is exposed to various stimuli, including temperature, mechanical stimuli, chemical substanc...

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Veröffentlicht in:	PloS one 2017-01, Vol.12 (1), p.e0169723-e0169723
Hauptverfasser:	Sakakibara, Akiko, Sakakibara, Shunsuke, Kusumoto, Junya, Takeda, Daisuke, Hasegawa, Takumi, Akashi, Masaya, Minamikawa, Tsutomu, Hashikawa, Kazunobu, Terashi, Hiroto, Komori, Takahide
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alcohol Alcohol Drinking Alcohol use Alcoholic beverages Analysis Apoptosis Biology and Life Sciences Buccal mucosa Cancer Capsaicin receptors Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cations Dental materials Development and progression Diagnosis Drinking (Alcoholic beverages) Epithelium External stimuli Female Gene expression Genetic aspects Gingiva - metabolism Health aspects Humans Immunohistochemistry Male Maxillofacial surgery Mechanical stimuli Medicine Medicine and Health Sciences Middle Aged Mouth cancer Mouth Mucosa - metabolism Mouth Neoplasms - genetics Mouth Neoplasms - metabolism Mouth Neoplasms - pathology mRNA Oral cancer Oral cavity Oral squamous cell carcinoma Patients pH effects Physiology Plastic surgery Protein Isoforms - genetics Protein Isoforms - metabolism Receptors Research and analysis methods Risk analysis Risk factors RNA, Messenger - metabolism Rodents Sensitivity enhancement Skin Smoking Social Sciences Squamous cell carcinoma Stimuli Surgery Tobacco Tongue Tongue - metabolism Transformation Transient receptor potential proteins TRPV Cation Channels - genetics TRPV Cation Channels - metabolism University graduates Up-Regulation
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