Income in Multiple Sclerosis Patients with Different Disease Phenotypes
Multiple sclerosis (MS) is a disease with profound heterogeneity in clinical course. To analyze sources and levels of income among MS patients in relation to disease phenotype with a special focus on identifying differences/similarities between primary progressive MS (PPMS) and secondary progressive...
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| creator | Kavaliunas, Andrius Manouchehrinia, Ali Danylaite Karrenbauer, Virginija Gyllensten, Hanna Glaser, Anna Alexanderson, Kristina Hillert, Jan |
| description | Multiple sclerosis (MS) is a disease with profound heterogeneity in clinical course.
To analyze sources and levels of income among MS patients in relation to disease phenotype with a special focus on identifying differences/similarities between primary progressive MS (PPMS) and secondary progressive MS (SPMS).
A total of 6890 MS patients aged 21-64 years and living in Sweden in 2010 were identified for this cross-sectional study. Descriptive statistics, logistic, truncated linear, and zero-inflated negative binomial regression models were used to estimate differences in income between SPMS, PPMS and relapsing-remitting MS (RRMS) patients.
RRMS patients earned almost twice as much as PPMS and SPMS patients (on average SEK 204,500, SEK 114,500, and SEK 79,800 in 2010, respectively). The difference in earnings between PPMS and SPMS was not statistically significant when analyzed with multivariable regression. The estimated odds ratio for PPMS patients to have income from earnings was not significantly different from SPMS patients (95% CI 0.98 to 1.59). PPMS and RRMS patients were less likely to receive benefits when compared to SPMS patients (by 6% and 27% lower, respectively).
Our findings argue for similarities between PPMS and SPMS and highlight the socioeconomic importance of preventing RRMS patients convert to SPMS. |
| doi_str_mv | 10.1371/journal.pone.0169460 |
| format | Article |
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To analyze sources and levels of income among MS patients in relation to disease phenotype with a special focus on identifying differences/similarities between primary progressive MS (PPMS) and secondary progressive MS (SPMS).
A total of 6890 MS patients aged 21-64 years and living in Sweden in 2010 were identified for this cross-sectional study. Descriptive statistics, logistic, truncated linear, and zero-inflated negative binomial regression models were used to estimate differences in income between SPMS, PPMS and relapsing-remitting MS (RRMS) patients.
RRMS patients earned almost twice as much as PPMS and SPMS patients (on average SEK 204,500, SEK 114,500, and SEK 79,800 in 2010, respectively). The difference in earnings between PPMS and SPMS was not statistically significant when analyzed with multivariable regression. The estimated odds ratio for PPMS patients to have income from earnings was not significantly different from SPMS patients (95% CI 0.98 to 1.59). PPMS and RRMS patients were less likely to receive benefits when compared to SPMS patients (by 6% and 27% lower, respectively).
Our findings argue for similarities between PPMS and SPMS and highlight the socioeconomic importance of preventing RRMS patients convert to SPMS.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0169460</identifier><identifier>PMID: 28081163</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Analogies ; Biology and Life Sciences ; Clinical trials ; Comparative analysis ; Country of birth ; Disease ; Earth Sciences ; Economic aspects ; Education ; Estimates ; Female ; Genotype & phenotype ; Humans ; Income ; Male ; Medicine and Health Sciences ; Middle Aged ; Models, Economic ; Multiple sclerosis ; Multiple Sclerosis - economics ; Neurology ; Neurosciences ; Patients ; People and Places ; Phenotype ; Phenotypes ; Physical Sciences ; Population ; Profits ; Ratios ; Regression analysis ; Regression models ; Research and Analysis Methods ; Socio-economic aspects ; Socioeconomic Factors ; Statistical analysis ; Studies ; Variables ; Wages and salaries</subject><ispartof>PloS one, 2017-01, Vol.12 (1), p.e0169460-e0169460</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Kavaliunas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Kavaliunas et al 2017 Kavaliunas et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c763t-99c0d4169c5bd84d1066604f66fc1057608140da545dda56881a211eea222f2f3</citedby><cites>FETCH-LOGICAL-c763t-99c0d4169c5bd84d1066604f66fc1057608140da545dda56881a211eea222f2f3</cites><orcidid>0000-0003-4638-3230</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5231357/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5231357/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28081163$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:135043007$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><contributor>Aktas, Orhan</contributor><creatorcontrib>Kavaliunas, Andrius</creatorcontrib><creatorcontrib>Manouchehrinia, Ali</creatorcontrib><creatorcontrib>Danylaite Karrenbauer, Virginija</creatorcontrib><creatorcontrib>Gyllensten, Hanna</creatorcontrib><creatorcontrib>Glaser, Anna</creatorcontrib><creatorcontrib>Alexanderson, Kristina</creatorcontrib><creatorcontrib>Hillert, Jan</creatorcontrib><title>Income in Multiple Sclerosis Patients with Different Disease Phenotypes</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Multiple sclerosis (MS) is a disease with profound heterogeneity in clinical course.
To analyze sources and levels of income among MS patients in relation to disease phenotype with a special focus on identifying differences/similarities between primary progressive MS (PPMS) and secondary progressive MS (SPMS).
A total of 6890 MS patients aged 21-64 years and living in Sweden in 2010 were identified for this cross-sectional study. Descriptive statistics, logistic, truncated linear, and zero-inflated negative binomial regression models were used to estimate differences in income between SPMS, PPMS and relapsing-remitting MS (RRMS) patients.
RRMS patients earned almost twice as much as PPMS and SPMS patients (on average SEK 204,500, SEK 114,500, and SEK 79,800 in 2010, respectively). The difference in earnings between PPMS and SPMS was not statistically significant when analyzed with multivariable regression. The estimated odds ratio for PPMS patients to have income from earnings was not significantly different from SPMS patients (95% CI 0.98 to 1.59). PPMS and RRMS patients were less likely to receive benefits when compared to SPMS patients (by 6% and 27% lower, respectively).
Our findings argue for similarities between PPMS and SPMS and highlight the socioeconomic importance of preventing RRMS patients convert to SPMS.</description><subject>Adult</subject><subject>Age</subject><subject>Analogies</subject><subject>Biology and Life Sciences</subject><subject>Clinical trials</subject><subject>Comparative analysis</subject><subject>Country of birth</subject><subject>Disease</subject><subject>Earth Sciences</subject><subject>Economic aspects</subject><subject>Education</subject><subject>Estimates</subject><subject>Female</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Income</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Models, Economic</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - economics</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Patients</subject><subject>People and Places</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Physical Sciences</subject><subject>Population</subject><subject>Profits</subject><subject>Ratios</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Research and Analysis Methods</subject><subject>Socio-economic aspects</subject><subject>Socioeconomic Factors</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Variables</subject><subject>Wages and 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one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kavaliunas, Andrius</au><au>Manouchehrinia, Ali</au><au>Danylaite Karrenbauer, Virginija</au><au>Gyllensten, Hanna</au><au>Glaser, Anna</au><au>Alexanderson, Kristina</au><au>Hillert, Jan</au><au>Aktas, Orhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Income in Multiple Sclerosis Patients with Different Disease Phenotypes</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-01-12</date><risdate>2017</risdate><volume>12</volume><issue>1</issue><spage>e0169460</spage><epage>e0169460</epage><pages>e0169460-e0169460</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Multiple sclerosis (MS) is a disease with profound heterogeneity in clinical course.
To analyze sources and levels of income among MS patients in relation to disease phenotype with a special focus on identifying differences/similarities between primary progressive MS (PPMS) and secondary progressive MS (SPMS).
A total of 6890 MS patients aged 21-64 years and living in Sweden in 2010 were identified for this cross-sectional study. Descriptive statistics, logistic, truncated linear, and zero-inflated negative binomial regression models were used to estimate differences in income between SPMS, PPMS and relapsing-remitting MS (RRMS) patients.
RRMS patients earned almost twice as much as PPMS and SPMS patients (on average SEK 204,500, SEK 114,500, and SEK 79,800 in 2010, respectively). The difference in earnings between PPMS and SPMS was not statistically significant when analyzed with multivariable regression. The estimated odds ratio for PPMS patients to have income from earnings was not significantly different from SPMS patients (95% CI 0.98 to 1.59). PPMS and RRMS patients were less likely to receive benefits when compared to SPMS patients (by 6% and 27% lower, respectively).
Our findings argue for similarities between PPMS and SPMS and highlight the socioeconomic importance of preventing RRMS patients convert to SPMS.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28081163</pmid><doi>10.1371/journal.pone.0169460</doi><tpages>e0169460</tpages><orcidid>https://orcid.org/0000-0003-4638-3230</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Analogies Biology and Life Sciences Clinical trials Comparative analysis Country of birth Disease Earth Sciences Economic aspects Education Estimates Female Genotype & phenotype Humans Income Male Medicine and Health Sciences Middle Aged Models, Economic Multiple sclerosis Multiple Sclerosis - economics Neurology Neurosciences Patients People and Places Phenotype Phenotypes Physical Sciences Population Profits Ratios Regression analysis Regression models Research and Analysis Methods Socio-economic aspects Socioeconomic Factors Statistical analysis Studies Variables Wages and salaries |
| title | Income in Multiple Sclerosis Patients with Different Disease Phenotypes |
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