Antibody Array Revealed PRL-3 Affects Protein Phosphorylation and Cytokine Secretion

Phosphatase of regenerating liver 3 (PRL-3) promotes cancer metastasis and progression via increasing cell motility and invasiveness, however the mechanism is still not fully understood. Previous reports showed that PRL-3 increases the phosphorylation of many important proteins and suspected that PR...

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Veröffentlicht in:	PloS one 2017-01, Vol.12 (1), p.e0169665
Hauptverfasser:	Yang, Yongyong, Lian, Shenyi, Meng, Lin, Qu, Like, Shou, Chengchao
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Biochemistry Biology and Life Sciences Cancer Cancer metastasis Cell adhesion & migration Cell Line, Tumor Cell migration Cell Movement - genetics Colorectal cancer Cytokines Cytokines - genetics Cytokines - secretion Development and progression Education Gene Expression Gene Knockdown Techniques Genetic aspects Humans Invasiveness Janus kinase 2 Janus Kinase 2 - metabolism Kinases Laboratories Liver Liver cancer Medicine and Health Sciences Metabolism Metastases Metastasis Molecular biology Motility Neoplasm Proteins - genetics Neoplasm Proteins - metabolism NF-kappa B - metabolism NF-κB protein Phosphatase Phosphoproteins - metabolism Phosphorylation Physical Sciences Physiological aspects Protein arrays Protein Tyrosine Phosphatases - genetics Protein Tyrosine Phosphatases - metabolism Proteins Proteome Proteomics - methods Rodents Serine Signal Transduction Signaling Stat3 protein Threonine Tyrosine
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