Agent-Based Modeling of Mitochondria Links Sub-Cellular Dynamics to Cellular Homeostasis and Heterogeneity

Mitochondria are semi-autonomous organelles that supply energy for cellular biochemistry through oxidative phosphorylation. Within a cell, hundreds of mobile mitochondria undergo fusion and fission events to form a dynamic network. These morphological and mobility dynamics are essential for maintain...

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Veröffentlicht in:	PloS one 2017-01, Vol.12 (1), p.e0168198-e0168198
Hauptverfasser:	Dalmasso, Giovanni, Marin Zapata, Paula Andrea, Brady, Nathan Ryan, Hamacher-Brady, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Agent-based models Analysis Autophagy Behavior Biochemistry Bioenergetics Biology Biology and Life Sciences Biosynthesis Cancer Cellular manufacture Computer and Information Sciences Computer Simulation Cytology Dynamics Energy consumption Energy demand Energy measurement Fission Heterogeneity Homeostasis Immunology Kinases Mathematical models Medical research Medicine and Health Sciences Membrane Fusion Mitochondria Mitochondria - physiology Mobility Models, Biological Morphology Organelle Biogenesis Organelles Oxidative phosphorylation Parameter identification Parameter sensitivity Phagocytosis Phosphorylation Physical Sciences Population Population biology Population dynamics Public health Research and Analysis Methods Sensitivity analysis Spatial distribution Stress Stresses Subpopulations
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