Experimental Mouse Model of Lumbar Ligamentum Flavum Hypertrophy

Lumbar spinal canal stenosis (LSCS) is one of the most common spinal disorders in elderly people, with the number of LSCS patients increasing due to the aging of the population. The ligamentum flavum (LF) is a spinal ligament located in the interior of the vertebral canal, and hypertrophy of the LF,...

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Veröffentlicht in:	PloS one 2017-01, Vol.12 (1), p.e0169717-e0169717
Hauptverfasser:	Saito, Takeyuki, Yokota, Kazuya, Kobayakawa, Kazu, Hara, Masamitsu, Kubota, Kensuke, Harimaya, Katsumi, Kawaguchi, Kenichi, Hayashida, Mitsumasa, Matsumoto, Yoshihiro, Doi, Toshio, Shiba, Keiichiro, Nakashima, Yasuharu, Okada, Seiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aging Angiogenesis Animals Biology and Life Sciences Chemokines Collagen Collagen - metabolism Compression Development and progression Disease Models, Animal Female Fibers Fibrosis Gene Expression Genetic aspects Geriatrics Humans Hypertrophy Infiltration Injuries Kinases Ligamentum Flavum - diagnostic imaging Ligamentum Flavum - metabolism Ligamentum Flavum - pathology Lumbar Vertebrae Macrophages Macrophages - metabolism Medical research Medicine and Health Sciences Mice Mice, Transgenic Older people Patients Physical Sciences Physiological aspects Research and Analysis Methods RNA, Messenger - genetics Rodents Spinal cord injuries Stenosis Stress Stress, Mechanical Stresses Studies Surgery Transforming growth factor Transforming growth factor-b1 Transforming growth factors Vascular endothelial growth factor Vertebrae Young Adult
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