Chronological Profiling of Plasma Native Peptides after Hepatectomy in Pigs: Toward the Discovery of Human Biomarkers for Liver Regeneration

Liver regeneration after partial hepatectomy (PHx) is a time-dependent process, which is tightly regulated by multiple signaling cascades. Failure of this complex process leads to posthepatectomy liver failure (PHLF), which is associated with a high rate of mortality. Thus, it is extremely important...

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Veröffentlicht in:	PloS one 2017-01, Vol.12 (1), p.e0167647-e0167647
Hauptverfasser:	Iguchi, Kohta, Hatano, Etsuro, Nirasawa, Takashi, Iwasaki, Noriyuki, Sato, Motohiko, Yamamoto, Gen, Yamanaka, Kenya, Okamoto, Tatsuya, Kasai, Yosuke, Nakamura, Naohiko, Fuji, Hiroaki, Sakai, Tomohito, Kakuda, Nobuto, Seo, Satoru, Taura, Kojiro, Tashiro, Kei, Uemoto, Shinji, Ikegawa, Masaya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Beads Biology and life sciences Biomarkers Care and treatment Cascades Chromatography, High Pressure Liquid Clinical trials Computer and Information Sciences Diagnostic systems Feasibility studies Female Fragmentation Fragments Gastrointestinal surgery Gene expression Hemoglobin Hepatectomy Histones Hogs Humans Liver Liver diseases Liver Regeneration Livestock Medical research Medicine Medicine and Health Sciences Peptides Peptides - blood Physiological aspects Plasma Proteins Regeneration Regeneration (Biology) ROC Curve Rodents Science Signaling Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Surgical outcomes Swine Tandem Mass Spectrometry
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