IDH1 R132H Mutation Enhances Cell Migration by Activating AKT-mTOR Signaling Pathway, but Sensitizes Cells to 5-FU Treatment as NADPH and GSH Are Reduced

Mutations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) gene were recently discovered in vast majority of World Health Organization (WHO) grade II/III gliomas. This study is to understand the effects of IDH1 R132H mutation in gliomagenesis and to develop new strategies to treat glioma with IDH...

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Veröffentlicht in:	PloS one 2017-01, Vol.12 (1), p.e0169038-e0169038
Hauptverfasser:	Zhu, Huixia, Zhang, Ye, Chen, Jianfeng, Qiu, Jiangdong, Huang, Keting, Wu, Mindan, Xia, Chunlin
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Analysis Antioxidants Assaying Biology and Life Sciences Blotting, Western Brain cancer Care and treatment Cell adhesion & migration Cell death Cell growth Cell Line Cell migration Cell Movement - drug effects Cell Movement - genetics Cell Proliferation Chemotherapy Dehydrogenase Dehydrogenases Fluorouracil - pharmacology Gene mutation Genetic aspects Glioma Glioma - genetics Glioma - metabolism Gliomas Glutathione - metabolism Humans Isocitrate dehydrogenase Isocitrate Dehydrogenase - genetics Isocitrate Dehydrogenase - metabolism Kinases Medicine and Health Sciences Metabolism Metabolites Motility Mutation Mutation - genetics NADP NADP - metabolism Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Proteins Quality Research and Analysis Methods Risk factors Signal transduction Signal Transduction - genetics Signal Transduction - physiology Signaling TOR protein TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism
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