Spleen Tyrosine Kinase Is Involved in the CD38 Signal Transduction Pathway in Chronic Lymphocytic Leukemia

The survival and proliferation of CLL cells depends on microenvironmental contacts in lymphoid organs. CD38 is a cell surface receptor that plays an important role in survival and proliferation signaling in CLL. In this study we demonstrate SYK's direct involvement in the CD38 signaling pathway...

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Veröffentlicht in:	PloS one 2016-12, Vol.11 (12), p.e0169159-e0169159
Hauptverfasser:	Benkisser-Petersen, Marco, Buchner, Maike, Dörffel, Arlette, Dühren-von-Minden, Marcus, Claus, Rainer, Kläsener, Kathrin, Leberecht, Kerstin, Burger, Meike, Dierks, Christine, Jumaa, Hassan, Malavasi, Fabio, Reth, Michael, Veelken, Hendrik, Duyster, Justus, Zirlik, Katja
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation ADP-ribosyl Cyclase 1 - biosynthesis ADP-ribosyl Cyclase 1 - metabolism ADP-ribosyl Cyclase 1 - pharmacology Adult Aged Aged, 80 and over AKT protein Analysis Apoptosis Apoptosis - drug effects Biology Biology and Life Sciences Care and treatment CD38 antigen Cell Movement - drug effects Cell proliferation Cell surface Cell Survival Cellular signal transduction Chemokine CXCL12 - metabolism Chronic lymphocytic leukemia Clinical trials CXCL12 protein Epigenetics Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Female Hematology Humans Immunology Inhibition Inhibitors Kinases Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - pathology Lymphatic leukemia Male Mcl-1 protein Medical prognosis Medicine Medicine and Health Sciences Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - metabolism Membrane Glycoproteins - pharmacology Middle Aged Multiple myeloma Myeloid Cell Leukemia Sequence 1 Protein - biosynthesis Oncology Organs Oxazines - pharmacology Patients Phosphorylation Phosphorylation - drug effects Protein-tyrosine kinase Proto-Oncogene Proteins c-akt - metabolism Pyridines - pharmacology Research and Analysis Methods Risk factors Signal transduction Signaling Spleen Stem cells Stimulation Studies Survival Syk Kinase - antagonists & inhibitors Syk Kinase - metabolism Syk protein Transplants & implants Tumor Cells, Cultured Tyrosine
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