Src Inhibition Can Synergize with Gemcitabine and Reverse Resistance in Triple Negative Breast Cancer Cells via the AKT/c-Jun Pathway

Gemcitabine-based chemotherapy remains one of the standards in management of metastatic breast cancer. However, intrinsic and acquired resistance to gemcitabine inevitably occurs. The aims of this study were to assess the efficacy of the combination of src inhibition and gemcitabine in gemcitabine-r...

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Veröffentlicht in:	PloS one 2016-12, Vol.11 (12), p.e0169230-e0169230
Hauptverfasser:	Wu, Zhen-Hua, Lin, Chen, Liu, Ming-Ming, Zhang, Jian, Tao, Zhong-Hua, Hu, Xi-Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Angiogenesis Anticancer properties Antimetabolites, Antineoplastic - pharmacology Antineoplastic Combined Chemotherapy Protocols - pharmacology Antitumor activity Apoptosis Apoptosis - drug effects Bax protein bcl-2-Associated X Protein - biosynthesis Bcl-x protein bcl-X Protein - biosynthesis Benzodioxoles - pharmacology Biology and life sciences Breast cancer c-Jun protein Cancer CD44 antigen Cell adhesion & migration Cell migration Cell Movement - drug effects Cell Proliferation - drug effects Cell self-renewal Chemotherapy Cytometry Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Dosage and administration Drug resistance Drug Resistance, Neoplasm - genetics Drug Synergism Drug therapy Drug tolerance Enzyme Inhibitors - pharmacology Epidermal growth factor Female Flow cytometry Focal Adhesion Kinase 1 - biosynthesis Gemcitabine Gene Expression Regulation, Neoplastic Humans Hyaluronan Receptors - biosynthesis Immunological tolerance Inhibition Inhibitor of Apoptosis Proteins - biosynthesis JNK Mitogen-Activated Protein Kinases - metabolism Kinases Laboratories Matrix Metalloproteinase 3 - biosynthesis Medical prognosis Medical research Medicine and Health Sciences Metastases Metastasis Oct-4 protein Octamer Transcription Factor-3 - biosynthesis Oncology Plasmids Proteins Proto-Oncogene Proteins c-akt - metabolism Quinazolines - pharmacology Research and Analysis Methods RNA Interference RNA, Small Interfering - genetics Signal transduction siRNA Src protein src-Family Kinases - antagonists & inhibitors src-Family Kinases - genetics Stem cells Survivin Synergism Transcription factors Triple negative breast cancer Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - pathology Tumor Cells, Cultured
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