Association of ABCB1 and SLC22A16 Gene Polymorphisms with Incidence of Doxorubicin-Induced Febrile Neutropenia: A Survey of Iranian Breast Cancer Patients

Breast cancer is the most common cancer in women worldwide. Doxorubicin-based chemotherapy is used to treat breast cancer patients; however, neutropenia is a common hematologic side effect and can be life-threatening. The ABCB1 and SLC22A16 genes encode proteins that are essential for doxorubicin tr...

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Veröffentlicht in:	PloS one 2016-12, Vol.11 (12), p.e0168519-e0168519
Hauptverfasser:	Faraji, Abolfazl, Dehghan Manshadi, Hamid Reza, Mobaraki, Maryam, Zare, Mahkameh, Houshmand, Massoud
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alleles Analysis Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use ATP Binding Cassette Transporter, Sub-Family B - genetics Biology and Life Sciences Biotechnology Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Cancer Cancer therapies Care and treatment Case-Control Studies Chemotherapy Deoxyribonucleic acid DNA Doxorubicin Doxorubicin - adverse effects Doxorubicin - therapeutic use Enzymes Febrile Neutropenia - chemically induced Febrile Neutropenia - genetics Female Genes Genetic aspects Genetic engineering Genetic polymorphisms Genetic testing Genotype Glycoproteins Health risks Humans Incidence Iran Medicine and Health Sciences Middle Aged Mutation Neutropenia Neutrophils Oncology Organic Cation Transport Proteins - genetics Patients Polymorphism, Single Nucleotide - genetics Proteins Quality Research and Analysis Methods Risk factors Statistical analysis Young Adult
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