Involvement of Renin-Angiotensin System in Retinopathy of Prematurity - A Possible Target for Therapeutic Intervention

Examining the Retinal Renin Angiotensin System (RRAS) in the ROP neonates and analyzing the possibility of modulating the RRAS to prevent the progression in Oxygen Induced Retinopathy (OIR) model. Vitreous of ROP patients (n = 44, median age 5.5 months) was quantified for RRAS components, VEGF, HIF-...

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Veröffentlicht in:	PloS one 2016-12, Vol.11 (12), p.e0168809-e0168809
Hauptverfasser:	Nath, Madhu, Chandra, Parijat, Halder, Nabanita, Singh, Baskar, Deorari, Ashok Kumar, Kumar, Atul, Azad, Rajvardhan, Velpandian, Thirumurthy
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Angiotensin-converting enzyme inhibitors Animals Bevacizumab Biology and Life Sciences Chromatography Collagen Collagen - metabolism Development and progression Diabetes Diabetic retinopathy Electroretinograms Electroretinography Enzymes Female Gene Expression Regulation - drug effects Genetic aspects Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Intervention Liquid chromatography Male Mass spectroscopy Medicine and Health Sciences Molecular Targeted Therapy Monoclonal antibodies Neonates Neovascularization, Pathologic - complications Oxygen Pediatrics Peptidyl-dipeptidase A Pharmacology Physiological aspects Proteins Rats Rats, Wistar Renin Renin-angiotensin system Renin-Angiotensin System - drug effects Research and Analysis Methods Retina Retina - diagnostic imaging Retinopathy Retinopathy of prematurity Retinopathy of Prematurity - drug therapy Retinopathy of Prematurity - genetics Retinopathy of Prematurity - metabolism Retinopathy of Prematurity - physiopathology Rodents Spectroscopy Structure-function relationships Studies Surgery Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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