Loss of TRPV4 Function Suppresses Inflammatory Fibrosis Induced by Alkali-Burning Mouse Corneas

In humans suffering from pulmonary disease and a mouse model, transient receptor potential vanilloid 4 (TRPV4) channel activation contributes to fibrosis. As a corneal alkali burn induces the same response, we determined if such an effect is also attributable to TRPV4 activation in mice. Accordingly...

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Veröffentlicht in:	PloS one 2016-12, Vol.11 (12), p.e0167200-e0167200
Hauptverfasser:	Okada, Yuka, Shirai, Kumi, Miyajima, Masayasu, Reinach, Peter S, Yamanaka, Osamu, Sumioka, Takayoshi, Kokado, Masahide, Tomoyose, Katsuo, Saika, Shizuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - genetics Activation Alkalies - pharmacology Animal models Animals Bioindicators Biology and Life Sciences Biomarkers Bone marrow Bone marrow transplantation Burning Collagen Cornea Cornea - drug effects Cornea - pathology Corneal Opacity - complications Cytokines Eye Burns - chemically induced Eye Burns - complications Eye Burns - genetics Eye Burns - pathology Fibroblasts Fibrosis Gene expression Gene Expression Regulation - drug effects Gene Knockout Techniques Genetically modified mice Immune system Immunohistochemistry Infiltration Inflammation Inflammation - pathology Interleukin 6 Interleukin-6 - genetics Laboratory animals Leukocytes Leukocytes (polymorphonuclear) Lung diseases Macrophages Medical research Medicine and Health Sciences Mice Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Muscles Polymerase chain reaction Research and Analysis Methods Risk factors Rodents Scars Smooth muscle Transforming growth factor Transforming Growth Factor beta - genetics Transforming growth factor-b Transient receptor potential proteins Transparency Transplantation TRPV Cation Channels - deficiency TRPV Cation Channels - genetics TRPV Cation Channels - metabolism Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Wound healing
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