Silibinin Inhibits Platelet-Derived Growth Factor-Driven Cell Proliferation via Downregulation of N-Glycosylation in Human Tenon's Fibroblasts in a Proteasome-Dependent Manner

The objective of this study was to evaluate the effects of silibinin on cell proliferation in platelet-derived growth factor (PDGF)-treated human Tenon's fibroblasts (HTFs). The effect of silibinin on cell proliferation in PDGF-treated HTFs was determined by examining the expression of prolifer...

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Veröffentlicht in:	PloS one 2016-12, Vol.11 (12), p.e0168765-e0168765
Hauptverfasser:	Chen, Yi-Hao, Chen, Ching-Long, Lu, Da-Wen, Liang, Chang-Min, Tai, Ming-Cheng, Chen, Jiann-Torng
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biology and Life Sciences Cancer Cell cycle Cell growth Cell Line Cell proliferation Cell Proliferation - drug effects Cyclin D1 Cyclin-dependent kinase 4 Cyclins Cytometry Down-Regulation - drug effects Fibroblasts Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Filtration Flow cytometry Glaucoma Glycosylation Glycosylation - drug effects Growth factors Hospitals Humans In vivo methods and tests Inflammation Kinases Leupeptins - pharmacology Liver diseases Medicine and Health Sciences Milk thistle Nitrogen - metabolism Physiological aspects Platelet-derived growth factor Platelet-Derived Growth Factor - metabolism Proliferating cell nuclear antigen Properties Prostate Proteasome Endopeptidase Complex - metabolism Proteasomes Receptor, Platelet-Derived Growth Factor beta - metabolism Scars Science Signal transduction Signaling Silibinin Silymarin - pharmacology Surgery Tenon Capsule - cytology Therapeutic applications Wound healing
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