NETosis before and after Hyperglycemic Control in Type 2 Diabetes Mellitus Patients

Diabetes is characterized by chronic inflammation, endothelial dysfunction, increased risk of infections and early cardiovascular disease. By releasing neutrophil extracellular traps (NETs), neutrophils kill bacteria and exert pro-inflammatory and pro-thrombotic activities. Increased NETosis has bee...

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Veröffentlicht in:	PloS one 2016-12, Vol.11 (12), p.e0168647-e0168647
Hauptverfasser:	Carestia, Agostina, Frechtel, Gustavo, Cerrone, Gloria, Linari, María A, Gonzalez, Claudio D, Casais, Patricia, Schattner, Mirta
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biochemistry Biology and Life Sciences Biomarkers Blood glucose Blood platelets Blood Platelets - metabolism Cardiovascular diseases Case-Control Studies Cholesterol Control Cytokines Cytokines - metabolism Cytometry Deoxyribonucleic acid Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - physiopathology Diagnosis DNA Enzyme-linked immunosorbent assay Extracellular Traps - drug effects Extracellular Traps - metabolism Female Fluorometers Fluorometry Glucose - metabolism Health risks Heart attacks Humans Hyperglycemia Hyperglycemia - drug therapy Hyperglycemia - etiology Hyperglycemia - metabolism Hypoglycemic Agents - pharmacology Immunology Inflammation Inflammation - epidemiology Inflammation - prevention & control Interleukin 6 Laboratories Leukocytes (neutrophilic) Male Medicine Medicine and Health Sciences Metformin Microscopy Middle Aged Mitochondrial DNA Molecular biology Neutrophils Nucleosomes P-selectin Patients Pharmacy Plasma levels Thrombosis Triglycerides Tumor necrosis factor-α Type 2 diabetes Von Willebrand factor Wound healing
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