The Agaricus blazei-Based Mushroom Extract, Andosan™, Protects against Intestinal Tumorigenesis in the A/J Min/+ Mouse

The novel A/J Min/+ mouse, which is a model for human Familial Adenomatous Polyposis (FAP), develops spontaneously multiple adenocarcinomas in the colon as well as in the small intestine. Agaricus blazei Murill (AbM) is an edible Basidiomycetes mushroom that has been used in traditional medicine aga...

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Veröffentlicht in:	PloS one 2016, Vol.11 (12), p.e0167754
Hauptverfasser:	Hetland, Geir, Eide, Dag M, Tangen, Jon M, Haugen, Mads H, Mirlashari, Mohammad R, Paulsen, Jan E
Format:	Artikel
Sprache:	eng
Schlagworte:	Agaricus - chemistry Agaricus - metabolism Animal models Animals Anticancer properties Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Antitumor activity Apoptosis Apoptosis - drug effects Basidiocarps Basidiomycota Biology and Life Sciences Caco-2 Cells Cancer Cancer therapies Collaboration Colon Colon cancer Colorectal cancer Colorectal carcinoma Cysteine Endopeptidases - metabolism Cytokines Cytokines - blood Cytotoxicity Dendritic cells Drinking water Enzyme-Linked Immunosorbent Assay Familial adenomatous polyposis Female Gene expression Genetic disorders Glucans Helper cells Humans Inflammation Inflammatory bowel disease Intestinal Mucosa - metabolism Intestine Intestines - pathology Legumain Lymphocytes T Male Medicine and Health Sciences Metastasis Mice Mice, Inbred C57BL Microscopy Microscopy, Fluorescence Mushrooms Oral administration Plant Extracts - chemistry Plant Extracts - pharmacology Polymorphism Polyps Protective Agents - chemistry Protective Agents - pharmacology Research and Analysis Methods Sepsis Single-nucleotide polymorphism Small intestine Studies Tumor cells Tumorigenesis Tumors β-Glucan
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