The Heat Shock Transcription Factor HSF1 Induces Ovarian Cancer Epithelial-Mesenchymal Transition in a 3D Spheroid Growth Model

Ovarian cancer is the most lethal gynecological cancer, with over 200,000 women diagnosed each year and over half of those cases leading to death. The proteotoxic stress-responsive transcription factor HSF1 is frequently overexpressed in a variety of cancers and is vital to cellular proliferation an...

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Veröffentlicht in:	PloS one 2016-12, Vol.11 (12), p.e0168389-e0168389
Hauptverfasser:	Powell, Chase D, Paullin, Trillitye R, Aoisa, Candice, Menzie, Christopher J, Ubaldini, Ashley, Westerheide, Sandy D
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and life sciences Biotechnology Cancer Cancer therapies Care and treatment Cell cycle Cell Line, Tumor Chemotherapy Computer simulation Deoxyribonucleic acid Development and progression DNA DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Epithelial-Mesenchymal Transition Female Gene expression Gene Knockdown Techniques Genes Genetic aspects Growth models Health aspects Heat shock Heat shock factors Heat Shock Transcription Factors HSF1 protein Humans Kinases Medical prognosis Medicine and Health Sciences Melanoma Mesenchyme Metastasis MicroRNAs Molecular biology Morphology Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Phosphorylation Polymerase chain reaction Proteins Research and Analysis Methods Spheroids Spheroids, Cellular - metabolism Survival analysis Three dimensional models Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Tumor cell lines Tumorigenesis Tumors Wound healing
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