Decreased Thalamocortical Connectivity in Chronic Ketamine Users
Disintegration in thalamocortical integration suggests its role in the mechanistic 'switch' from recreational to dysregulated drug seeking/addiction. In this study, we aimed to address whether thalamic nuclear groups show altered functional connectivity within the cerebral cortex in chroni...
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| creator | Liao, Yanhui Tang, Jinsong Liu, Jianbin Xie, An Yang, Mei Johnson, Maritza Wang, Xuyi Deng, Qijian Chen, Hongxian Xiang, Xiaojun Liu, Tieqiao Chen, Xiaogang Song, Ming Hao, Wei |
| description | Disintegration in thalamocortical integration suggests its role in the mechanistic 'switch' from recreational to dysregulated drug seeking/addiction. In this study, we aimed to address whether thalamic nuclear groups show altered functional connectivity within the cerebral cortex in chronic ketamine users. One hundred and thirty subjects (41 ketamine users and 89 control subjects) underwent rsfMRI (resting-state functional Magnetic Resonance Imaging). Based on partial correlation functional connectivity analysis we partitioned the thalamus into six nuclear groups that correspond well with human histology. Then, in the area of each nuclear group, the functional connectivity differences between the chronic ketamine user group and normal control group were investigated. We found that the ketamine user group showed significantly less connectivity between the thalamic nuclear groups and the cortical regions-of-interest, including the prefrontal cortex, the motor cortex /supplementary motor area, and the posterior parietal cortex. However, no increased thalamic connectivity was observed for these regions as compared with controls. This study provides the first evidence of abnormal thalamocortical connectivity of resting state brain activity in chronic ketamine users. Further understanding of pathophysiological mechanisms of the thalamus in addiction (ketamine addiction) may facilitate the evaluation of much-needed novel pharmacological agents for improved therapy of this complex disease. |
| doi_str_mv | 10.1371/journal.pone.0167381 |
| format | Article |
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In this study, we aimed to address whether thalamic nuclear groups show altered functional connectivity within the cerebral cortex in chronic ketamine users. One hundred and thirty subjects (41 ketamine users and 89 control subjects) underwent rsfMRI (resting-state functional Magnetic Resonance Imaging). Based on partial correlation functional connectivity analysis we partitioned the thalamus into six nuclear groups that correspond well with human histology. Then, in the area of each nuclear group, the functional connectivity differences between the chronic ketamine user group and normal control group were investigated. We found that the ketamine user group showed significantly less connectivity between the thalamic nuclear groups and the cortical regions-of-interest, including the prefrontal cortex, the motor cortex /supplementary motor area, and the posterior parietal cortex. However, no increased thalamic connectivity was observed for these regions as compared with controls. This study provides the first evidence of abnormal thalamocortical connectivity of resting state brain activity in chronic ketamine users. Further understanding of pathophysiological mechanisms of the thalamus in addiction (ketamine addiction) may facilitate the evaluation of much-needed novel pharmacological agents for improved therapy of this complex disease.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0167381</identifier><identifier>PMID: 27977717</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Addiction ; Addictions ; Adult ; Anesthetics, Dissociative - toxicity ; Biology and Life Sciences ; Brain ; Brain Mapping ; Brain research ; Cerebral cortex ; Cerebral Cortex - diagnostic imaging ; Cerebral Cortex - drug effects ; Cerebral Cortex - physiopathology ; Cocaine ; Complications and side effects ; Connectivity analysis ; Correlation analysis ; Cortex (motor) ; Cortex (parietal) ; Disintegration ; Dosage and administration ; Drug abuse ; Drug addiction ; Female ; Functional magnetic resonance imaging ; Functional Neuroimaging ; Histology ; Hospitals ; Humans ; Image Processing, Computer-Assisted ; Ketamine ; Ketamine - toxicity ; Laboratories ; Magnetic resonance ; Magnetic Resonance Imaging ; Male ; Medicine and Health Sciences ; Mental disorders ; Mental health ; Nerve Net - diagnostic imaging ; Nerve Net - drug effects ; Nerve Net - physiopathology ; Neural circuitry ; Neural networks ; Neural Pathways - drug effects ; Neural Pathways - physiopathology ; Neurobiology ; Neuroimaging ; Neurosciences ; Pharmacology ; Physical Sciences ; Physiological aspects ; Prefrontal cortex ; Psychiatry ; Research and Analysis Methods ; Schizophrenia ; Social Sciences ; Substance-Related Disorders - diagnostic imaging ; Substance-Related Disorders - physiopathology ; Supplementary motor area ; Thalamus ; Thalamus - diagnostic imaging ; Thalamus - drug effects ; Thalamus - physiopathology ; User groups ; Young Adult</subject><ispartof>PloS one, 2016-12, Vol.11 (12), p.e0167381</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Liao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Liao et al 2016 Liao et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-67d9479d98a272714c95d437306f0de4ad67456be2b8573248329f94d9fa4c2e3</citedby><cites>FETCH-LOGICAL-c725t-67d9479d98a272714c95d437306f0de4ad67456be2b8573248329f94d9fa4c2e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157971/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157971/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27977717$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Stamatakis, Emmanuel Andreas</contributor><creatorcontrib>Liao, Yanhui</creatorcontrib><creatorcontrib>Tang, Jinsong</creatorcontrib><creatorcontrib>Liu, Jianbin</creatorcontrib><creatorcontrib>Xie, An</creatorcontrib><creatorcontrib>Yang, Mei</creatorcontrib><creatorcontrib>Johnson, Maritza</creatorcontrib><creatorcontrib>Wang, Xuyi</creatorcontrib><creatorcontrib>Deng, Qijian</creatorcontrib><creatorcontrib>Chen, Hongxian</creatorcontrib><creatorcontrib>Xiang, Xiaojun</creatorcontrib><creatorcontrib>Liu, Tieqiao</creatorcontrib><creatorcontrib>Chen, Xiaogang</creatorcontrib><creatorcontrib>Song, Ming</creatorcontrib><creatorcontrib>Hao, Wei</creatorcontrib><title>Decreased Thalamocortical Connectivity in Chronic Ketamine Users</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Disintegration in thalamocortical integration suggests its role in the mechanistic 'switch' from recreational to dysregulated drug seeking/addiction. In this study, we aimed to address whether thalamic nuclear groups show altered functional connectivity within the cerebral cortex in chronic ketamine users. One hundred and thirty subjects (41 ketamine users and 89 control subjects) underwent rsfMRI (resting-state functional Magnetic Resonance Imaging). Based on partial correlation functional connectivity analysis we partitioned the thalamus into six nuclear groups that correspond well with human histology. Then, in the area of each nuclear group, the functional connectivity differences between the chronic ketamine user group and normal control group were investigated. We found that the ketamine user group showed significantly less connectivity between the thalamic nuclear groups and the cortical regions-of-interest, including the prefrontal cortex, the motor cortex /supplementary motor area, and the posterior parietal cortex. However, no increased thalamic connectivity was observed for these regions as compared with controls. This study provides the first evidence of abnormal thalamocortical connectivity of resting state brain activity in chronic ketamine users. Further understanding of pathophysiological mechanisms of the thalamus in addiction (ketamine addiction) may facilitate the evaluation of much-needed novel pharmacological agents for improved therapy of this complex disease.</description><subject>Addiction</subject><subject>Addictions</subject><subject>Adult</subject><subject>Anesthetics, Dissociative - toxicity</subject><subject>Biology and Life Sciences</subject><subject>Brain</subject><subject>Brain Mapping</subject><subject>Brain research</subject><subject>Cerebral cortex</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Cocaine</subject><subject>Complications and side effects</subject><subject>Connectivity analysis</subject><subject>Correlation analysis</subject><subject>Cortex (motor)</subject><subject>Cortex (parietal)</subject><subject>Disintegration</subject><subject>Dosage and administration</subject><subject>Drug abuse</subject><subject>Drug addiction</subject><subject>Female</subject><subject>Functional magnetic resonance imaging</subject><subject>Functional Neuroimaging</subject><subject>Histology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Ketamine</subject><subject>Ketamine - toxicity</subject><subject>Laboratories</subject><subject>Magnetic resonance</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Mental disorders</subject><subject>Mental health</subject><subject>Nerve Net - diagnostic imaging</subject><subject>Nerve Net - drug effects</subject><subject>Nerve Net - physiopathology</subject><subject>Neural circuitry</subject><subject>Neural networks</subject><subject>Neural Pathways - drug effects</subject><subject>Neural Pathways - physiopathology</subject><subject>Neurobiology</subject><subject>Neuroimaging</subject><subject>Neurosciences</subject><subject>Pharmacology</subject><subject>Physical Sciences</subject><subject>Physiological aspects</subject><subject>Prefrontal cortex</subject><subject>Psychiatry</subject><subject>Research and Analysis Methods</subject><subject>Schizophrenia</subject><subject>Social Sciences</subject><subject>Substance-Related Disorders - diagnostic imaging</subject><subject>Substance-Related Disorders - physiopathology</subject><subject>Supplementary motor area</subject><subject>Thalamus</subject><subject>Thalamus - diagnostic imaging</subject><subject>Thalamus - drug effects</subject><subject>Thalamus - physiopathology</subject><subject>User groups</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkk1vEzEQhlcIREvhHyBYCQnBIcFfu7YviCp8RVSqBC1Xy7FnE0cbO7V3K_rvcZptlUU9IB9sjZ95xzN-i-IlRlNMOf6wDn30up1ug4cpwjWnAj8qjrGkZFITRB8fnI-KZymtEaqoqOunxRHhknOO-XHx6TOYCDqBLS9WutWbYELsnNFtOQveg-nctetuSufL2SoG70z5Azq9cR7KywQxPS-eNLpN8GLYT4rLr18uZt8nZ-ff5rPTs4nhpOomNbeScWml0IQTjpmRlWWUU1Q3yALTtuasqhdAFqLilDBBiWwks7LRzBCgJ8Xrve62DUkNzSeFRYUwRbhCmZjvCRv0Wm2j2-h4o4J26jYQ4lLpXWstqIoSu6hxJTDnTNZC4gYMEkSwmjJrSNb6OFTrFxuwBnwXdTsSHd94t1LLcK0qXOXZ4izwbhCI4aqH1KmNSwbaVnsI_e27JRNIiB365h_04e4GaqlzA843Idc1O1F1yjhDGFHCMzV9gMrLwsaZ7JTG5fgo4f0oITMd_OmWuk9JzX_9_H_2_PeYfXvArkC33SqFtu9c8GkMsj1oYkgpQnM_ZIzUzuh301A7o6vB6Dnt1eEH3SfdOZv-Bdyl9Tk</recordid><startdate>20161215</startdate><enddate>20161215</enddate><creator>Liao, Yanhui</creator><creator>Tang, Jinsong</creator><creator>Liu, Jianbin</creator><creator>Xie, An</creator><creator>Yang, Mei</creator><creator>Johnson, Maritza</creator><creator>Wang, Xuyi</creator><creator>Deng, Qijian</creator><creator>Chen, Hongxian</creator><creator>Xiang, Xiaojun</creator><creator>Liu, Tieqiao</creator><creator>Chen, Xiaogang</creator><creator>Song, Ming</creator><creator>Hao, Wei</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20161215</creationdate><title>Decreased Thalamocortical Connectivity in Chronic Ketamine Users</title><author>Liao, Yanhui ; Tang, Jinsong ; Liu, Jianbin ; Xie, An ; Yang, Mei ; Johnson, Maritza ; Wang, Xuyi ; Deng, Qijian ; Chen, Hongxian ; Xiang, Xiaojun ; Liu, Tieqiao ; Chen, Xiaogang ; Song, Ming ; Hao, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c725t-67d9479d98a272714c95d437306f0de4ad67456be2b8573248329f94d9fa4c2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Addiction</topic><topic>Addictions</topic><topic>Adult</topic><topic>Anesthetics, Dissociative - 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In this study, we aimed to address whether thalamic nuclear groups show altered functional connectivity within the cerebral cortex in chronic ketamine users. One hundred and thirty subjects (41 ketamine users and 89 control subjects) underwent rsfMRI (resting-state functional Magnetic Resonance Imaging). Based on partial correlation functional connectivity analysis we partitioned the thalamus into six nuclear groups that correspond well with human histology. Then, in the area of each nuclear group, the functional connectivity differences between the chronic ketamine user group and normal control group were investigated. We found that the ketamine user group showed significantly less connectivity between the thalamic nuclear groups and the cortical regions-of-interest, including the prefrontal cortex, the motor cortex /supplementary motor area, and the posterior parietal cortex. However, no increased thalamic connectivity was observed for these regions as compared with controls. This study provides the first evidence of abnormal thalamocortical connectivity of resting state brain activity in chronic ketamine users. Further understanding of pathophysiological mechanisms of the thalamus in addiction (ketamine addiction) may facilitate the evaluation of much-needed novel pharmacological agents for improved therapy of this complex disease.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27977717</pmid><doi>10.1371/journal.pone.0167381</doi><tpages>e0167381</tpages><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1850130150 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Addiction Addictions Adult Anesthetics, Dissociative - toxicity Biology and Life Sciences Brain Brain Mapping Brain research Cerebral cortex Cerebral Cortex - diagnostic imaging Cerebral Cortex - drug effects Cerebral Cortex - physiopathology Cocaine Complications and side effects Connectivity analysis Correlation analysis Cortex (motor) Cortex (parietal) Disintegration Dosage and administration Drug abuse Drug addiction Female Functional magnetic resonance imaging Functional Neuroimaging Histology Hospitals Humans Image Processing, Computer-Assisted Ketamine Ketamine - toxicity Laboratories Magnetic resonance Magnetic Resonance Imaging Male Medicine and Health Sciences Mental disorders Mental health Nerve Net - diagnostic imaging Nerve Net - drug effects Nerve Net - physiopathology Neural circuitry Neural networks Neural Pathways - drug effects Neural Pathways - physiopathology Neurobiology Neuroimaging Neurosciences Pharmacology Physical Sciences Physiological aspects Prefrontal cortex Psychiatry Research and Analysis Methods Schizophrenia Social Sciences Substance-Related Disorders - diagnostic imaging Substance-Related Disorders - physiopathology Supplementary motor area Thalamus Thalamus - diagnostic imaging Thalamus - drug effects Thalamus - physiopathology User groups Young Adult |
| title | Decreased Thalamocortical Connectivity in Chronic Ketamine Users |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T08%3A32%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Decreased%20Thalamocortical%20Connectivity%20in%20Chronic%20Ketamine%20Users&rft.jtitle=PloS%20one&rft.au=Liao,%20Yanhui&rft.date=2016-12-15&rft.volume=11&rft.issue=12&rft.spage=e0167381&rft.pages=e0167381-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0167381&rft_dat=%3Cgale_plos_%3EA474010327%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1850130150&rft_id=info:pmid/27977717&rft_galeid=A474010327&rft_doaj_id=oai_doaj_org_article_532db6158177496891fec08284634dc2&rfr_iscdi=true |