Foot-and-Mouth Disease Virus-Associated Abortion and Vertical Transmission following Acute Infection in Cattle under Natural Conditions
Foot-and-mouth disease (FMD) is a highly contagious and economically important viral disease of cloven-hoofed animals, including domestic and wild host species. During recent FMD outbreaks in India, spontaneous abortions were reported amongst FMD-affected and asymptomatic cows. The current study was...
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| Veröffentlicht in: | PloS one 2016-12, Vol.11 (12), p.e0167163-e0167163 |
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| description | Foot-and-mouth disease (FMD) is a highly contagious and economically important viral disease of cloven-hoofed animals, including domestic and wild host species. During recent FMD outbreaks in India, spontaneous abortions were reported amongst FMD-affected and asymptomatic cows. The current study was an opportunistic investigation of these naturally occurring bovine abortions to assess causality of abortion and vertical transmission of FMDV from infected cows to fetuses. For this purpose, fetal tissue samples of eight abortuses (heart, liver, kidney, spleen, palatine tonsil, umbilical cord, soft palate, tongue, lungs, and submandibular lymph node) were collected and screened by various detection methods, including viral genome detection, virus isolation, and immunomicroscopy. Amongst these cases, gross pathological changes were observed in 3 abortuses. Gross pathological findings included blood-tinged peritoneal and pleural effusions and myocarditis. Hearts of infected calves had mild to moderate degeneration and necrosis of the myocardium with moderate infiltration by mixed inflammatory cells. Localization of FMDV antigen was demonstrated in lungs and soft palate by immunomicroscopy. FMDV serotype O viral genome was recovered from 7 of 8 cases. Infectious FMDV serotype O was rescued by chemical transfection of the total RNA extracted from three soft palate samples and was sequenced to confirm 100% identity of the VP1 (capsid) coding region with isolates collected from infected cattle during the acute phase of infection. Based upon these findings, it may be concluded that FMDV-associated abortion occurred among the infected pregnant cows included within this study and FMDV was subsequently transmitted vertically to fetuses. This is the first documentation of FMDV-associated abortions in cattle. |
| doi_str_mv | 10.1371/journal.pone.0167163 |
| format | Article |
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Agricultural Research Service ; Xing, Zheng</creatorcontrib><description>Foot-and-mouth disease (FMD) is a highly contagious and economically important viral disease of cloven-hoofed animals, including domestic and wild host species. During recent FMD outbreaks in India, spontaneous abortions were reported amongst FMD-affected and asymptomatic cows. The current study was an opportunistic investigation of these naturally occurring bovine abortions to assess causality of abortion and vertical transmission of FMDV from infected cows to fetuses. For this purpose, fetal tissue samples of eight abortuses (heart, liver, kidney, spleen, palatine tonsil, umbilical cord, soft palate, tongue, lungs, and submandibular lymph node) were collected and screened by various detection methods, including viral genome detection, virus isolation, and immunomicroscopy. Amongst these cases, gross pathological changes were observed in 3 abortuses. Gross pathological findings included blood-tinged peritoneal and pleural effusions and myocarditis. Hearts of infected calves had mild to moderate degeneration and necrosis of the myocardium with moderate infiltration by mixed inflammatory cells. Localization of FMDV antigen was demonstrated in lungs and soft palate by immunomicroscopy. FMDV serotype O viral genome was recovered from 7 of 8 cases. Infectious FMDV serotype O was rescued by chemical transfection of the total RNA extracted from three soft palate samples and was sequenced to confirm 100% identity of the VP1 (capsid) coding region with isolates collected from infected cattle during the acute phase of infection. Based upon these findings, it may be concluded that FMDV-associated abortion occurred among the infected pregnant cows included within this study and FMDV was subsequently transmitted vertically to fetuses. This is the first documentation of FMDV-associated abortions in cattle.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0167163</identifier><identifier>PMID: 27977708</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abortion ; Abortion, Veterinary - virology ; Animal diseases ; Animal reproduction ; Animals ; BASIC BIOLOGICAL SCIENCES ; Biology and Life Sciences ; Bovidae ; Calves ; Cattle ; Cattle diseases ; Cattle Diseases - virology ; Complications and side effects ; Degeneration ; Disease transmission ; Economic conditions ; Economic importance ; Epidemics ; Female ; Fetus - virology ; Fetuses ; Foot & mouth disease ; Foot and mouth disease ; Foot-and-Mouth Disease - complications ; Foot-and-Mouth Disease - virology ; Foot-and-mouth disease virus ; Foot-and-Mouth Disease Virus - isolation & purification ; Genomes ; Health aspects ; Heart ; Heart diseases ; India ; Infections ; Infectious Disease Transmission, Vertical - veterinary ; Infiltration ; Inflammation ; Kidneys ; Liver ; Localization ; Lungs ; Lymph nodes ; Medicine and Health Sciences ; Myocarditis ; Myocardium ; Nitric oxide ; Outbreaks ; Palate ; Pathogenesis ; Peritoneum ; Pregnancy ; Research and analysis methods ; Ribonucleic acid ; RNA ; Sheep ; Spleen ; Suidae ; Tongue ; Tonsil ; Transfection ; Umbilical cord ; Viral diseases ; Viruses ; VP1 protein</subject><ispartof>PloS one, 2016-12, Vol.11 (12), p.e0167163-e0167163</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). 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Agricultural Research Service</creatorcontrib><title>Foot-and-Mouth Disease Virus-Associated Abortion and Vertical Transmission following Acute Infection in Cattle under Natural Conditions</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Foot-and-mouth disease (FMD) is a highly contagious and economically important viral disease of cloven-hoofed animals, including domestic and wild host species. During recent FMD outbreaks in India, spontaneous abortions were reported amongst FMD-affected and asymptomatic cows. The current study was an opportunistic investigation of these naturally occurring bovine abortions to assess causality of abortion and vertical transmission of FMDV from infected cows to fetuses. For this purpose, fetal tissue samples of eight abortuses (heart, liver, kidney, spleen, palatine tonsil, umbilical cord, soft palate, tongue, lungs, and submandibular lymph node) were collected and screened by various detection methods, including viral genome detection, virus isolation, and immunomicroscopy. Amongst these cases, gross pathological changes were observed in 3 abortuses. Gross pathological findings included blood-tinged peritoneal and pleural effusions and myocarditis. Hearts of infected calves had mild to moderate degeneration and necrosis of the myocardium with moderate infiltration by mixed inflammatory cells. Localization of FMDV antigen was demonstrated in lungs and soft palate by immunomicroscopy. FMDV serotype O viral genome was recovered from 7 of 8 cases. Infectious FMDV serotype O was rescued by chemical transfection of the total RNA extracted from three soft palate samples and was sequenced to confirm 100% identity of the VP1 (capsid) coding region with isolates collected from infected cattle during the acute phase of infection. Based upon these findings, it may be concluded that FMDV-associated abortion occurred among the infected pregnant cows included within this study and FMDV was subsequently transmitted vertically to fetuses. 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isolation & purification</subject><subject>Genomes</subject><subject>Health aspects</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>India</subject><subject>Infections</subject><subject>Infectious Disease Transmission, Vertical - veterinary</subject><subject>Infiltration</subject><subject>Inflammation</subject><subject>Kidneys</subject><subject>Liver</subject><subject>Localization</subject><subject>Lungs</subject><subject>Lymph nodes</subject><subject>Medicine and Health Sciences</subject><subject>Myocarditis</subject><subject>Myocardium</subject><subject>Nitric oxide</subject><subject>Outbreaks</subject><subject>Palate</subject><subject>Pathogenesis</subject><subject>Peritoneum</subject><subject>Pregnancy</subject><subject>Research and analysis methods</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Sheep</subject><subject>Spleen</subject><subject>Suidae</subject><subject>Tongue</subject><subject>Tonsil</subject><subject>Transfection</subject><subject>Umbilical cord</subject><subject>Viral diseases</subject><subject>Viruses</subject><subject>VP1 protein</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk8uO0zAUhiMEYoaBN0AQgYRgkeJLEjsbpKowUGlgJBi6tRz7uHWV2iV2uDwBr417mVGLZjHKIpb9_b_9H_tk2VOMRpgy_Hbph97JbrT2DkYI1wzX9F52ihtKipogev9gfJI9CmGJUEV5XT_MTghrGGOIn2Z_z72PhXS6-OyHuMjf2wAyQD6z_RCKcQheWRlB5-PW99F6lyc2n0EaK9nlV710YWVD2KwY33X-l3XzfKyGCPnUGVBbjXX5RMbYQT44DX3-RcahT_KJd9puiPA4e2BkF-DJ_n-WfT__cDX5VFxcfpxOxheFYhWJRaPaqqlqpkutEOY1o7SCljVSK1BtSVotOanrFE8b3qIKAWHKMI2RwUgqoGfZ853vuvNB7GsYBOYVwhThskzEdEdoL5di3duV7P8IL63YTvh-LuQmfQeiBaKNMYpTRkqjEZetVpSTtlaGVq1MXu_2uw3tCtIZXUyxj0yPV5xdiLn_KSpcpQw0GbzYGfgQrQjKRlAL5Z1LhRXpGfCS4QS93u_S-x8DhCjSjSjoOunAD9twTckRr-6EYtKQEpGEvvwPvb1ae2ouU0GsMz7lUBtTMS5ZiTAqEU_U6BYqfRpWNsUBY9P8keDNkSAxEX7HuRxCENNvX-_OXs6O2VcH7AJkFxfBd8P2DR6D5Q5UvQ-hB3NzaRhtCo-vqyE2_Sf2_Zdkzw4v_EZ03XD0H6AELG0</recordid><startdate>20161215</startdate><enddate>20161215</enddate><creator>Ranjan, Rajeev</creator><creator>Biswal, Jitendra K</creator><creator>Subramaniam, Saravanan</creator><creator>Singh, Karam Pal</creator><creator>Stenfeldt, Carolina</creator><creator>Rodriguez, Luis L</creator><creator>Pattnaik, Bramhadev</creator><creator>Arzt, Jonathan</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>OIOZB</scope><scope>OTOTI</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20161215</creationdate><title>Foot-and-Mouth Disease Virus-Associated Abortion and Vertical Transmission following Acute Infection in Cattle under Natural Conditions</title><author>Ranjan, Rajeev ; Biswal, Jitendra K ; Subramaniam, Saravanan ; Singh, Karam Pal ; Stenfeldt, Carolina ; Rodriguez, Luis L ; Pattnaik, Bramhadev ; Arzt, Jonathan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c752t-9cb59567d4dc01867335eb79adcecb42bda8266797df8b050e27cf7d10f10ace3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Abortion</topic><topic>Abortion, Veterinary - 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Agricultural Research Service</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Foot-and-Mouth Disease Virus-Associated Abortion and Vertical Transmission following Acute Infection in Cattle under Natural Conditions</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-12-15</date><risdate>2016</risdate><volume>11</volume><issue>12</issue><spage>e0167163</spage><epage>e0167163</epage><pages>e0167163-e0167163</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Foot-and-mouth disease (FMD) is a highly contagious and economically important viral disease of cloven-hoofed animals, including domestic and wild host species. During recent FMD outbreaks in India, spontaneous abortions were reported amongst FMD-affected and asymptomatic cows. The current study was an opportunistic investigation of these naturally occurring bovine abortions to assess causality of abortion and vertical transmission of FMDV from infected cows to fetuses. For this purpose, fetal tissue samples of eight abortuses (heart, liver, kidney, spleen, palatine tonsil, umbilical cord, soft palate, tongue, lungs, and submandibular lymph node) were collected and screened by various detection methods, including viral genome detection, virus isolation, and immunomicroscopy. Amongst these cases, gross pathological changes were observed in 3 abortuses. Gross pathological findings included blood-tinged peritoneal and pleural effusions and myocarditis. Hearts of infected calves had mild to moderate degeneration and necrosis of the myocardium with moderate infiltration by mixed inflammatory cells. Localization of FMDV antigen was demonstrated in lungs and soft palate by immunomicroscopy. FMDV serotype O viral genome was recovered from 7 of 8 cases. Infectious FMDV serotype O was rescued by chemical transfection of the total RNA extracted from three soft palate samples and was sequenced to confirm 100% identity of the VP1 (capsid) coding region with isolates collected from infected cattle during the acute phase of infection. Based upon these findings, it may be concluded that FMDV-associated abortion occurred among the infected pregnant cows included within this study and FMDV was subsequently transmitted vertically to fetuses. This is the first documentation of FMDV-associated abortions in cattle.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27977708</pmid><doi>10.1371/journal.pone.0167163</doi><tpages>e0167163</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-12, Vol.11 (12), p.e0167163-e0167163 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1850130144 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abortion Abortion, Veterinary - virology Animal diseases Animal reproduction Animals BASIC BIOLOGICAL SCIENCES Biology and Life Sciences Bovidae Calves Cattle Cattle diseases Cattle Diseases - virology Complications and side effects Degeneration Disease transmission Economic conditions Economic importance Epidemics Female Fetus - virology Fetuses Foot & mouth disease Foot and mouth disease Foot-and-Mouth Disease - complications Foot-and-Mouth Disease - virology Foot-and-mouth disease virus Foot-and-Mouth Disease Virus - isolation & purification Genomes Health aspects Heart Heart diseases India Infections Infectious Disease Transmission, Vertical - veterinary Infiltration Inflammation Kidneys Liver Localization Lungs Lymph nodes Medicine and Health Sciences Myocarditis Myocardium Nitric oxide Outbreaks Palate Pathogenesis Peritoneum Pregnancy Research and analysis methods Ribonucleic acid RNA Sheep Spleen Suidae Tongue Tonsil Transfection Umbilical cord Viral diseases Viruses VP1 protein |
| title | Foot-and-Mouth Disease Virus-Associated Abortion and Vertical Transmission following Acute Infection in Cattle under Natural Conditions |
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