Genomic Characterization of Metformin Hepatic Response

Metformin is used as a first-line therapy for type 2 diabetes (T2D) and prescribed for numerous other diseases. However, its mechanism of action in the liver has yet to be characterized in a systematic manner. To comprehensively identify genes and regulatory elements associated with metformin treatm...

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Veröffentlicht in:	PLoS genetics 2016-11, Vol.12 (11), p.e1006449
Hauptverfasser:	Luizon, Marcelo R, Eckalbar, Walter L, Wang, Yao, Jones, Stacy L, Smith, Robin P, Laurance, Megan, Lin, Lawrence, Gallins, Paul J, Etheridge, Amy S, Wright, Fred, Zhou, Yihui, Molony, Cliona, Innocenti, Federico, Yee, Sook Wah, Giacomini, Kathleen M, Ahituv, Nadav
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 3 - genetics Adaptor Proteins, Signal Transducing - genetics AMP-Activated Protein Kinases - biosynthesis AMP-Activated Protein Kinases - genetics Ataxia Telangiectasia Mutated Proteins - biosynthesis Ataxia Telangiectasia Mutated Proteins - genetics Bioengineering Bioinformatics Biology and life sciences Colleges & universities DEAD-box RNA Helicases - genetics Diabetes Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - pathology Dosage and administration Enhancer Elements, Genetic Gene Knockdown Techniques Genes Genetics Genomes Gluconeogenesis - genetics Haplotypes Hepatocytes - drug effects Hepatocytes - metabolism Humans Kinases Knowledge management Linkage Disequilibrium Liver - drug effects Liver - metabolism Medicine and Health Sciences Metformin Metformin - adverse effects Metformin - therapeutic use Observations Pharmacogenomics Pharmacy Polymorphism, Single Nucleotide
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