The Listeria monocytogenes PASTA Kinase PrkA and Its Substrate YvcK Are Required for Cell Wall Homeostasis, Metabolism, and Virulence

Obstacles to bacterial survival and replication in the cytosol of host cells, and the mechanisms used by bacterial pathogens to adapt to this niche are not well understood. Listeria monocytogenes is a well-studied Gram-positive foodborne pathogen that has evolved to invade and replicate within the h...

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Veröffentlicht in:	PLoS pathogens 2016-11, Vol.12 (11), p.e1006001
Hauptverfasser:	Pensinger, Daniel A, Boldon, Kyle M, Chen, Grischa Y, Vincent, William J B, Sherman, Kyle, Xiong, Meng, Schaenzer, Adam J, Forster, Emily R, Coers, Jörn, Striker, Rob, Sauer, John-Demian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacillus subtilis Biology and Life Sciences Blotting, Western Cell division Cell Wall - metabolism Cell walls Colleges & universities Cyclic AMP-Dependent Protein Kinases - metabolism Disease Models, Animal Experiments Funding Genetic aspects Glycerol Homeostasis Homeostasis - physiology Immunology Infections Kinases Listeria Listeria monocytogenes Listeria monocytogenes - pathogenicity Listeriosis - metabolism Mass Spectrometry Medical research Medicine Medicine and Health Sciences Metabolism Mice Mice, Inbred C57BL Microbial Sensitivity Tests Mortality Mycobacterium tuberculosis Pathogens Peptides Phosphorylation Physical sciences Physiological aspects Proteins Public health Virulence (Microbiology) Virulence - physiology Virulence Factors - metabolism
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