A Novel Zebrafish ret Heterozygous Model of Hirschsprung Disease Identifies a Functional Role for mapk10 as a Modifier of Enteric Nervous System Phenotype Severity

Hirschsprung disease (HSCR) is characterized by absence of enteric neurons from the distal colon and severe intestinal dysmotility. To understand the pathophysiology and genetics of HSCR we developed a unique zebrafish model that allows combined genetic, developmental and in vivo physiological studi...

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Veröffentlicht in:	PLoS genetics 2016-11, Vol.12 (11), p.e1006439-e1006439
Hauptverfasser:	Heanue, Tiffany A, Boesmans, Werend, Bell, Donald M, Kawakami, Koichi, Vanden Berghe, Pieter, Pachnis, Vassilis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology and Life Sciences Colon - innervation Colon - pathology Crick, Francis Danio rerio Disease Disease Models, Animal Enteric Nervous System - metabolism Enteric Nervous System - pathology Funding Genetic aspects Genetics Health aspects Hirschsprung Disease - genetics Hirschsprung Disease - metabolism Hirschsprung Disease - pathology Hirschsprung's disease Homeostasis Humans Kinases Laboratories Medicine and Health Sciences Mitogen-Activated Protein Kinase 10 - genetics Mitogen-activated protein kinases Motility Mutation Nervous system Neural circuitry Neurons Neurons - metabolism Neurons - pathology Neurosciences Phenotype Phenotypes Physiology Proteins Proto-Oncogene Proteins c-ret - genetics Proto-Oncogene Proteins c-ret - metabolism Research and Analysis Methods Studies Zebrafish Zebrafish - genetics
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