Clinical Symptoms, Imaging Features and Cyst Distribution in the Cerebrospinal Fluid Compartments in Patients with Extraparenchymal Neurocysticercosis
Extraparenchymal neurocysticercosis has an aggressive course because cysts in the cerebrospinal fluid compartments induce acute inflammatory reactions. The relationships between symptoms, imaging findings, lesion type and location remain poorly understood. In this retrospective clinical records-base...
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| creator | Bazan, Rodrigo Hamamoto Filho, Pedro Tadao Luvizutto, Gustavo José Nunes, Hélio Rubens de Carvalho Odashima, Newton Satoru Dos Santos, Antônio Carlos Elias Júnior, Jorge Zanini, Marco Antônio Fleury, Agnès Takayanagui, Osvaldo Massaiti |
| description | Extraparenchymal neurocysticercosis has an aggressive course because cysts in the cerebrospinal fluid compartments induce acute inflammatory reactions. The relationships between symptoms, imaging findings, lesion type and location remain poorly understood. In this retrospective clinical records-based study, we describe the clinical symptoms, magnetic resonance imaging features, and cyst distribution in the CSF compartments of 36 patients with extraparenchymal neurocysticercosis. Patients were recruited between 1995 and 2010 and median follow up was 38 months. During all the follow up time we found that 75% (27/36) of the patients had symptoms related to raised intracranial pressure sometime, 72.2% (26/36) cysticercotic meningitis, 61.1% (22/36) seizures, and 50.0% (18/36) headaches unrelated to intracranial pressure. Regarding lesion types, 77.8% (28/36) of patients presented with grape-like cysts, 22.2% (8/36) giant cysts, and 61.1% (22/36) contrast-enhancing lesions. Hydrocephalus occurred in 72.2% (26/36) of patients during the follow-up period. All patients had cysts in the subarachnoid space and 41.7% (15/36) had at least one cyst in some ventricle. Cysts were predominantly located in the posterior fossa (31 patients) and supratentorial basal cisterns (19 patients). The fourth ventricle was the main compromised ventricle (10 patients). Spinal cysts were more frequent than previously reported (11.1%, 4/36). Our findings are useful for both diagnosis and treatment selection in patients with neurocysticercosis. |
| doi_str_mv | 10.1371/journal.pntd.0005115 |
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The relationships between symptoms, imaging findings, lesion type and location remain poorly understood. In this retrospective clinical records-based study, we describe the clinical symptoms, magnetic resonance imaging features, and cyst distribution in the CSF compartments of 36 patients with extraparenchymal neurocysticercosis. Patients were recruited between 1995 and 2010 and median follow up was 38 months. During all the follow up time we found that 75% (27/36) of the patients had symptoms related to raised intracranial pressure sometime, 72.2% (26/36) cysticercotic meningitis, 61.1% (22/36) seizures, and 50.0% (18/36) headaches unrelated to intracranial pressure. Regarding lesion types, 77.8% (28/36) of patients presented with grape-like cysts, 22.2% (8/36) giant cysts, and 61.1% (22/36) contrast-enhancing lesions. Hydrocephalus occurred in 72.2% (26/36) of patients during the follow-up period. All patients had cysts in the subarachnoid space and 41.7% (15/36) had at least one cyst in some ventricle. Cysts were predominantly located in the posterior fossa (31 patients) and supratentorial basal cisterns (19 patients). The fourth ventricle was the main compromised ventricle (10 patients). Spinal cysts were more frequent than previously reported (11.1%, 4/36). Our findings are useful for both diagnosis and treatment selection in patients with neurocysticercosis.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0005115</identifier><identifier>PMID: 27828966</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Behavioral sciences ; Biology and Life Sciences ; Brain - diagnostic imaging ; Care and treatment ; Cerebrospinal Fluid - diagnostic imaging ; Cysticercosis ; Cysts ; Cysts - cerebrospinal fluid ; Diagnostic imaging ; Female ; Funding ; Humans ; Internal medicine ; Lesions ; Localization ; Magnetic Resonance Imaging ; Male ; Medical schools ; Medicine ; Medicine and Health Sciences ; Meningitis ; Middle Aged ; Mortality ; Nervous system ; Neurocysticercosis - cerebrospinal fluid ; Neurocysticercosis - diagnostic imaging ; Neurology ; Neurosciences ; NMR ; Nuclear magnetic resonance ; Psychiatry ; Research and Analysis Methods ; Retrospective Studies ; Risk factors ; Tropical diseases ; Young Adult</subject><ispartof>PLoS neglected tropical diseases, 2016-11, Vol.10 (11), p.e0005115-e0005115</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Bazan R, Hamamoto Filho PT, Luvizutto GJ, Nunes HRdC, Odashima NS, dos Santos AC, et al. (2016) Clinical Symptoms, Imaging Features and Cyst Distribution in the Cerebrospinal Fluid Compartments in Patients with Extraparenchymal Neurocysticercosis. PLoS Negl Trop Dis 10(11): e0005115. doi:10.1371/journal.pntd.0005115</rights><rights>2016 Bazan et al 2016 Bazan et al</rights><rights>2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Bazan R, Hamamoto Filho PT, Luvizutto GJ, Nunes HRdC, Odashima NS, dos Santos AC, et al. (2016) Clinical Symptoms, Imaging Features and Cyst Distribution in the Cerebrospinal Fluid Compartments in Patients with Extraparenchymal Neurocysticercosis. PLoS Negl Trop Dis 10(11): e0005115. doi:10.1371/journal.pntd.0005115</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c624t-daf0b7584392f17a7e3aa0625f8b7e543bcb9293c3945f1eb03aed1dd00951d43</citedby><cites>FETCH-LOGICAL-c624t-daf0b7584392f17a7e3aa0625f8b7e543bcb9293c3945f1eb03aed1dd00951d43</cites><orcidid>0000-0001-6436-9307</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102378/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102378/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27828966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bazan, Rodrigo</creatorcontrib><creatorcontrib>Hamamoto Filho, Pedro Tadao</creatorcontrib><creatorcontrib>Luvizutto, Gustavo José</creatorcontrib><creatorcontrib>Nunes, Hélio Rubens de Carvalho</creatorcontrib><creatorcontrib>Odashima, Newton Satoru</creatorcontrib><creatorcontrib>Dos Santos, Antônio Carlos</creatorcontrib><creatorcontrib>Elias Júnior, Jorge</creatorcontrib><creatorcontrib>Zanini, Marco Antônio</creatorcontrib><creatorcontrib>Fleury, Agnès</creatorcontrib><creatorcontrib>Takayanagui, Osvaldo Massaiti</creatorcontrib><title>Clinical Symptoms, Imaging Features and Cyst Distribution in the Cerebrospinal Fluid Compartments in Patients with Extraparenchymal Neurocysticercosis</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>Extraparenchymal neurocysticercosis has an aggressive course because cysts in the cerebrospinal fluid compartments induce acute inflammatory reactions. 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All patients had cysts in the subarachnoid space and 41.7% (15/36) had at least one cyst in some ventricle. Cysts were predominantly located in the posterior fossa (31 patients) and supratentorial basal cisterns (19 patients). The fourth ventricle was the main compromised ventricle (10 patients). Spinal cysts were more frequent than previously reported (11.1%, 4/36). Our findings are useful for both diagnosis and treatment selection in patients with neurocysticercosis.</description><subject>Adult</subject><subject>Aged</subject><subject>Behavioral sciences</subject><subject>Biology and Life Sciences</subject><subject>Brain - diagnostic imaging</subject><subject>Care and treatment</subject><subject>Cerebrospinal Fluid - diagnostic imaging</subject><subject>Cysticercosis</subject><subject>Cysts</subject><subject>Cysts - cerebrospinal fluid</subject><subject>Diagnostic imaging</subject><subject>Female</subject><subject>Funding</subject><subject>Humans</subject><subject>Internal medicine</subject><subject>Lesions</subject><subject>Localization</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical schools</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Meningitis</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Nervous system</subject><subject>Neurocysticercosis - 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The relationships between symptoms, imaging findings, lesion type and location remain poorly understood. In this retrospective clinical records-based study, we describe the clinical symptoms, magnetic resonance imaging features, and cyst distribution in the CSF compartments of 36 patients with extraparenchymal neurocysticercosis. Patients were recruited between 1995 and 2010 and median follow up was 38 months. During all the follow up time we found that 75% (27/36) of the patients had symptoms related to raised intracranial pressure sometime, 72.2% (26/36) cysticercotic meningitis, 61.1% (22/36) seizures, and 50.0% (18/36) headaches unrelated to intracranial pressure. Regarding lesion types, 77.8% (28/36) of patients presented with grape-like cysts, 22.2% (8/36) giant cysts, and 61.1% (22/36) contrast-enhancing lesions. Hydrocephalus occurred in 72.2% (26/36) of patients during the follow-up period. All patients had cysts in the subarachnoid space and 41.7% (15/36) had at least one cyst in some ventricle. Cysts were predominantly located in the posterior fossa (31 patients) and supratentorial basal cisterns (19 patients). The fourth ventricle was the main compromised ventricle (10 patients). Spinal cysts were more frequent than previously reported (11.1%, 4/36). Our findings are useful for both diagnosis and treatment selection in patients with neurocysticercosis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27828966</pmid><doi>10.1371/journal.pntd.0005115</doi><orcidid>https://orcid.org/0000-0001-6436-9307</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PLoS neglected tropical diseases, 2016-11, Vol.10 (11), p.e0005115-e0005115 |
| issn | 1935-2735 1935-2727 1935-2735 |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Adult Aged Behavioral sciences Biology and Life Sciences Brain - diagnostic imaging Care and treatment Cerebrospinal Fluid - diagnostic imaging Cysticercosis Cysts Cysts - cerebrospinal fluid Diagnostic imaging Female Funding Humans Internal medicine Lesions Localization Magnetic Resonance Imaging Male Medical schools Medicine Medicine and Health Sciences Meningitis Middle Aged Mortality Nervous system Neurocysticercosis - cerebrospinal fluid Neurocysticercosis - diagnostic imaging Neurology Neurosciences NMR Nuclear magnetic resonance Psychiatry Research and Analysis Methods Retrospective Studies Risk factors Tropical diseases Young Adult |
| title | Clinical Symptoms, Imaging Features and Cyst Distribution in the Cerebrospinal Fluid Compartments in Patients with Extraparenchymal Neurocysticercosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T15%3A34%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20Symptoms,%20Imaging%20Features%20and%20Cyst%20Distribution%20in%20the%20Cerebrospinal%20Fluid%20Compartments%20in%20Patients%20with%20Extraparenchymal%20Neurocysticercosis&rft.jtitle=PLoS%20neglected%20tropical%20diseases&rft.au=Bazan,%20Rodrigo&rft.date=2016-11-09&rft.volume=10&rft.issue=11&rft.spage=e0005115&rft.epage=e0005115&rft.pages=e0005115-e0005115&rft.issn=1935-2735&rft.eissn=1935-2735&rft_id=info:doi/10.1371/journal.pntd.0005115&rft_dat=%3Cgale_plos_%3EA478272761%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1849654531&rft_id=info:pmid/27828966&rft_galeid=A478272761&rft_doaj_id=oai_doaj_org_article_30d8ccd2891f413097dcc0f8d7e23c44&rfr_iscdi=true |