Isoflurane Exposure Induces Cell Death, Microglial Activation and Modifies the Expression of Genes Supporting Neurodevelopment and Cognitive Function in the Male Newborn Piglet Brain

Exposure of the brain to general anesthesia during early infancy may adversely affect its neural and cognitive development. The mechanisms mediating this are complex, incompletely understood and may be sexually dimorphic, but include developmentally inappropriate apoptosis, inflammation and a disrup...

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Veröffentlicht in:	PloS one 2016-11, Vol.11 (11), p.e0166784
Hauptverfasser:	Broad, Kevin D, Hassell, Jane, Fleiss, Bobbi, Kawano, Go, Ezzati, Mojgan, Rocha-Ferreira, Eridan, Hristova, Mariya, Bennett, Kate, Fierens, Igor, Burnett, Ryan, Chaban, Badr, Alonso-Alconada, Daniel, Oliver-Taylor, Aaron, Tachsidis, Ilias, Rostami, Jamshid, Gressens, Pierre, Sanders, Robert D, Robertson, Nicola J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Anesthesiology Anesthetics, General - pharmacology Animal cognition Animals Animals, Newborn Apoptosis Attention deficit hyperactivity disorder Biology and Life Sciences Brain Brain - cytology Brain - drug effects Brain - growth & development Brain - physiology Caspase Caspase-3 Caudate nucleus Cell activation Cell death Cell Death - drug effects Cognition - drug effects Cognitive ability Cognitive development College campuses Cortex (cingulate) Cortex (insular) DNA microarrays Dosage and administration EEG Electroencephalography Exposure Gene expression Gene Expression Regulation, Developmental - drug effects Genes Gray Matter - cytology Gray Matter - drug effects Gray Matter - growth & development Gray Matter - physiology Health aspects Hippocampus Hogs Infants Inflammation Intubation Isoflurane Isoflurane - pharmacology Male Males Medical research Medicine and Health Sciences Memory Microglia - cytology Microglia - drug effects Mortality Neonates Neural networks Neurodevelopment Neuroplasticity Nuclei (cytology) Oligodendrocytes Plasticity (neural) Psychopathology Putamen Recall Research and Analysis Methods Sexual dimorphism Substantia alba Surgical outcomes Swine Thalamus Time Factors Transcription White Matter - cytology White Matter - drug effects White Matter - growth & development White Matter - physiology Womens health
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