Effect of Regulatory Element DNA Methylation on Tissue-Type Plasminogen Activator Gene Expression

Expression of the tissue-type plasminogen activator gene (t-PA; gene name PLAT) is regulated, in part, by epigenetic mechanisms. We investigated the relationship between PLAT methylation and PLAT expression in five primary human cell types and six transformed cell lines. CpG methylation was analyzed...

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Veröffentlicht in:	PloS one 2016-12, Vol.11 (12), p.e0167588-e0167588
Hauptverfasser:	Dunoyer-Geindre, Sylvie, Rivier-Cordey, Anne-Sophie, Caetano, Carlos, Fish, Richard J, Kruithof, Egbert K O
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antigens Arteriosclerosis Binding sites Binding Sites - genetics Biology Biology and life sciences Brain cells Brain research Cancer Cell Line Cell lines CpG islands Deoxyribonucleic acid Diabetes DNA DNA methylation DNA Methylation - genetics Epigenesis, Genetic - genetics Epigenetics Fibrinolytic agents Fibroblasts Gene expression Genomes Health aspects HeLa Cells Histone deacetylase Humans Medical research Medicine and Health Sciences Melanoma Metabolism Methylation Mitochondrial DNA Oligonucleotides Plasmids Promoter Regions, Genetic - genetics Regulatory sequences Regulatory Sequences, Nucleic Acid - genetics Reporter gene Research and analysis methods RNA polymerase Secretion Sp1 protein Thrombosis Tissue Plasminogen Activator - genetics Transcription Initiation Site - physiology Transcription, Genetic - genetics
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