Mesenchymal Stromal Cells Promote Axonal Outgrowth Alone and Synergistically with Astrocytes via tPA

We reported that mesenchymal stromal cells (MSCs) enhance neurological recovery from experimental stroke and increase tissue plasminogen activator (tPA) expression in astrocytes. Here, we investigate mechanisms by which tPA mediates MSC enhanced axonal outgrowth. Primary murine neurons and astrocyte...

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Veröffentlicht in:	PloS one 2016-12, Vol.11 (12), p.e0168345-e0168345
Hauptverfasser:	Qian, Jian-Yong, Chopp, Michael, Liu, Zhongwu
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antibiotics Astrocytes Astrocytes - cytology Astrocytes - metabolism Axons Axons - metabolism Biology and Life Sciences Butadienes - chemistry Care and treatment Chambers Coculture Techniques Deprivation Embryos Engineering and Technology Enzyme Inhibitors - chemistry Extracellular Signal-Regulated MAP Kinases - metabolism Growth factors Inserts Kinases Laboratory animals Ligands Low density lipoprotein receptors Medicine and Health Sciences Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchyme Mice Mice, Inbred C57BL Mice, Knockout Microfluidics Neurites - metabolism Neurology Neurons Neurons - metabolism Nitriles - chemistry Oxygen Oxygen - metabolism Physical Sciences Proteins Receptor density Stem cells Stroke Stroke - metabolism Stromal cells Synergistic effect t-Plasminogen activator Tissue plasminogen activator Tissue Plasminogen Activator - metabolism
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