Limited Impact of Imatinib in a Murine Model of Sclerodermatous Chronic Graft-versus-Host Disease

Sclerodermatous chronic Graft-versus-Host Disease (scl-cGVHD) is one of the most severe form of cGVHD. The Platelet-derived Grotwth Factor (PDGF) and the Transforming Growth Factor-β (TGF-β) play a significant role in the fibrosing process occurring in scl-cGVHD. This prompted us to assess the impac...

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Veröffentlicht in:	PloS one 2016-12, Vol.11 (12), p.e0167997-e0167997
Hauptverfasser:	Belle, Ludovic, Fransolet, Gilles, Somja, Joan, Binsfeld, Marilène, Delvenne, Philippe, Drion, Pierre, Hannon, Muriel, Beguin, Yves, Ehx, Grégory, Baron, Frédéric
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal models Animals Antigens Biology and Life Sciences Blood Bone marrow Cancer CD8 antigen Cell growth Cell proliferation Cell Proliferation - drug effects Disease Models, Animal Dosage and administration Drug dosages Enzyme inhibitors Fibrosis Fuel consumption Graft versus host disease Graft vs Host Disease - drug therapy Graft vs Host Disease - immunology Graft vs Host Disease - physiopathology Graft vs. host disease Graft-versus-host reaction Growth factors GVHD Hematology Human health sciences Hématologie Imatinib Imatinib mesylate Imatinib Mesylate - therapeutic use Immunoregulation Inhibitor drugs Irradiation Laboratories Leukemia Lymphocytes Lymphocytes T Medical research Medicine Medicine and Health Sciences Mice Mice, Inbred BALB C Pathogenesis Pathology PDGF Phosphorylation Platelet-derived growth factor Platelet-Derived Growth Factor - metabolism Protein Kinase Inhibitors - therapeutic use Protein-tyrosine kinase Proto-Oncogene Proteins c-abl - metabolism Radiation Research and Analysis Methods Rodents Sciences de la santé humaine Scleroderma, Localized - drug therapy Scleroderma, Localized - immunology Scleroderma, Localized - physiopathology Sclerodermia Spleen Splenocytes Stem cell transplantation Stem cells Studies T-Lymphocyte Subsets - drug effects T-Lymphocytes - drug effects T-Lymphocytes - immunology TGF-Beta Transforming growth factor-a Transforming growth factor-b Transforming growth factors Transplantation Transplants & implants Tumors Tyrosine
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