High Serum Adiponectin Level Is a Risk Factor for Anemia in Japanese Men: A Prospective Observational Study of 1,029 Japanese Subjects
Erythroid abnormalities including anemia and polycythemia are often observed in the general clinical setting. Because recent studies reported that adiponectin negatively affects hematopoiesis, we performed a prospective observational study to assess the relationship between anemia and adiponectin, a...
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| creator | Kohno, Kei Narimatsu, Hiroto Shiono, Yosuke Suzuki, Ikuko Kato, Yuichi Sho, Ri Otani, Katsumi Ishizawa, Kenichi Yamashita, Hidetoshi Kubota, Isao Ueno, Yoshiyuki Kato, Takeo Fukao, Akira Kayama, Takamasa |
| description | Erythroid abnormalities including anemia and polycythemia are often observed in the general clinical setting. Because recent studies reported that adiponectin negatively affects hematopoiesis, we performed a prospective observational study to assess the relationship between anemia and adiponectin, as well as other parameters, in 1029 Japanese subjects (477 men and 552 women) 40 years of age and older. Body measurements, blood tests, and nutrition intake studies were performed at baseline, and 5 to 7 years later (follow-up). Hemoglobin (Hb) and hematocrit (Hct) levels in men with high serum adiponectin levels were lower at follow-up than at baseline. Multiple regression analysis showed that age, body mass index, adiponectin, and glutamic-pyruvic transaminase were significantly associated with erythroid-related variables (red blood cells, Hb, and Hct) in both men and women (P |
| doi_str_mv | 10.1371/journal.pone.0165511 |
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Because recent studies reported that adiponectin negatively affects hematopoiesis, we performed a prospective observational study to assess the relationship between anemia and adiponectin, as well as other parameters, in 1029 Japanese subjects (477 men and 552 women) 40 years of age and older. Body measurements, blood tests, and nutrition intake studies were performed at baseline, and 5 to 7 years later (follow-up). Hemoglobin (Hb) and hematocrit (Hct) levels in men with high serum adiponectin levels were lower at follow-up than at baseline. Multiple regression analysis showed that age, body mass index, adiponectin, and glutamic-pyruvic transaminase were significantly associated with erythroid-related variables (red blood cells, Hb, and Hct) in both men and women (P <0.05). In a logistic regression analysis, adiponectin, fasting blood glucose, and β-natriuretic peptide were significant risk factors for anemia in men, and blood urea nitrogen and amylase were significant risk factors in women. Physical features and nutrient intake were not risk factors for anemia. Our study demonstrates, both clinically and epidemiologically, that a high serum adiponectin level decreases the amounts of erythroid-related variables and is a risk factor for anemia in Japanese men.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0165511</identifier><identifier>PMID: 27918575</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abnormalities ; Adiponectin ; Adiponectin - blood ; Adult ; Aged ; Aged, 80 and over ; Alanine Transaminase - metabolism ; Amylases - metabolism ; Analysis ; Anemia ; Anemia - blood ; Anemia - etiology ; Anemia - metabolism ; Asian Continental Ancestry Group ; Atherosclerosis ; Biology and Life Sciences ; Blood ; Blood cells ; Blood Glucose - metabolism ; Blood tests ; Blood Urea Nitrogen ; Body mass ; Body mass index ; Body measurements ; Body size ; Bone marrow ; Cell adhesion & migration ; Diabetes ; Endocrinology ; Epidemiology ; Erythrocytes ; Female ; Follow-Up Studies ; Health aspects ; Health risk assessment ; Hematocrit ; Hematocrit - methods ; Hematology ; Hematopoiesis ; Hemoglobin ; Hemoglobins - metabolism ; Humans ; Insulin ; Internal medicine ; Iron ; Kidney diseases ; Laboratories ; Levels ; Male ; Medicine ; Medicine and Health Sciences ; Men ; Metabolism ; Middle age ; Middle Aged ; Multiple regression analysis ; Multivariate Analysis ; Neurology ; Nutrition ; Nutrition research ; Observational studies ; Older people ; Peptides ; Physical Sciences ; Polycythemia ; Prospective Studies ; Proteins ; Public health ; Regression Analysis ; Research and Analysis Methods ; Risk analysis ; Risk Factors ; Studies ; Transaminase ; University graduates ; Urea ; Womens health</subject><ispartof>PloS one, 2016-12, Vol.11 (12), p.e0165511-e0165511</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Kohno et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Kohno et al 2016 Kohno et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c791t-c0fc4d4ddca3a115450f2d08688d10b57405733c36c4a240fab051a9e65af0243</citedby><cites>FETCH-LOGICAL-c791t-c0fc4d4ddca3a115450f2d08688d10b57405733c36c4a240fab051a9e65af0243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137881/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137881/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27918575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Zirlik, Andreas</contributor><creatorcontrib>Kohno, Kei</creatorcontrib><creatorcontrib>Narimatsu, Hiroto</creatorcontrib><creatorcontrib>Shiono, Yosuke</creatorcontrib><creatorcontrib>Suzuki, Ikuko</creatorcontrib><creatorcontrib>Kato, Yuichi</creatorcontrib><creatorcontrib>Sho, Ri</creatorcontrib><creatorcontrib>Otani, Katsumi</creatorcontrib><creatorcontrib>Ishizawa, Kenichi</creatorcontrib><creatorcontrib>Yamashita, Hidetoshi</creatorcontrib><creatorcontrib>Kubota, Isao</creatorcontrib><creatorcontrib>Ueno, Yoshiyuki</creatorcontrib><creatorcontrib>Kato, Takeo</creatorcontrib><creatorcontrib>Fukao, Akira</creatorcontrib><creatorcontrib>Kayama, Takamasa</creatorcontrib><title>High Serum Adiponectin Level Is a Risk Factor for Anemia in Japanese Men: A Prospective Observational Study of 1,029 Japanese Subjects</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Erythroid abnormalities including anemia and polycythemia are often observed in the general clinical setting. Because recent studies reported that adiponectin negatively affects hematopoiesis, we performed a prospective observational study to assess the relationship between anemia and adiponectin, as well as other parameters, in 1029 Japanese subjects (477 men and 552 women) 40 years of age and older. Body measurements, blood tests, and nutrition intake studies were performed at baseline, and 5 to 7 years later (follow-up). Hemoglobin (Hb) and hematocrit (Hct) levels in men with high serum adiponectin levels were lower at follow-up than at baseline. Multiple regression analysis showed that age, body mass index, adiponectin, and glutamic-pyruvic transaminase were significantly associated with erythroid-related variables (red blood cells, Hb, and Hct) in both men and women (P <0.05). In a logistic regression analysis, adiponectin, fasting blood glucose, and β-natriuretic peptide were significant risk factors for anemia in men, and blood urea nitrogen and amylase were significant risk factors in women. Physical features and nutrient intake were not risk factors for anemia. Our study demonstrates, both clinically and epidemiologically, that a high serum adiponectin level decreases the amounts of erythroid-related variables and is a risk factor for anemia in Japanese men.</description><subject>Abnormalities</subject><subject>Adiponectin</subject><subject>Adiponectin - blood</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alanine Transaminase - metabolism</subject><subject>Amylases - metabolism</subject><subject>Analysis</subject><subject>Anemia</subject><subject>Anemia - blood</subject><subject>Anemia - etiology</subject><subject>Anemia - metabolism</subject><subject>Asian Continental Ancestry Group</subject><subject>Atherosclerosis</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Blood cells</subject><subject>Blood Glucose - metabolism</subject><subject>Blood tests</subject><subject>Blood Urea Nitrogen</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body measurements</subject><subject>Body size</subject><subject>Bone marrow</subject><subject>Cell adhesion & migration</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Epidemiology</subject><subject>Erythrocytes</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Hematocrit</subject><subject>Hematocrit - methods</subject><subject>Hematology</subject><subject>Hematopoiesis</subject><subject>Hemoglobin</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>Insulin</subject><subject>Internal medicine</subject><subject>Iron</subject><subject>Kidney diseases</subject><subject>Laboratories</subject><subject>Levels</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Men</subject><subject>Metabolism</subject><subject>Middle age</subject><subject>Middle Aged</subject><subject>Multiple regression analysis</subject><subject>Multivariate Analysis</subject><subject>Neurology</subject><subject>Nutrition</subject><subject>Nutrition research</subject><subject>Observational studies</subject><subject>Older people</subject><subject>Peptides</subject><subject>Physical Sciences</subject><subject>Polycythemia</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Public health</subject><subject>Regression Analysis</subject><subject>Research and Analysis Methods</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>Transaminase</subject><subject>University graduates</subject><subject>Urea</subject><subject>Womens 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Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kohno, Kei</au><au>Narimatsu, Hiroto</au><au>Shiono, Yosuke</au><au>Suzuki, Ikuko</au><au>Kato, Yuichi</au><au>Sho, Ri</au><au>Otani, Katsumi</au><au>Ishizawa, Kenichi</au><au>Yamashita, Hidetoshi</au><au>Kubota, Isao</au><au>Ueno, Yoshiyuki</au><au>Kato, Takeo</au><au>Fukao, Akira</au><au>Kayama, Takamasa</au><au>Zirlik, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High Serum Adiponectin Level Is a Risk Factor for Anemia in Japanese Men: A Prospective Observational Study of 1,029 Japanese Subjects</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-12-05</date><risdate>2016</risdate><volume>11</volume><issue>12</issue><spage>e0165511</spage><epage>e0165511</epage><pages>e0165511-e0165511</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Erythroid abnormalities including anemia and polycythemia are often observed in the general clinical setting. Because recent studies reported that adiponectin negatively affects hematopoiesis, we performed a prospective observational study to assess the relationship between anemia and adiponectin, as well as other parameters, in 1029 Japanese subjects (477 men and 552 women) 40 years of age and older. Body measurements, blood tests, and nutrition intake studies were performed at baseline, and 5 to 7 years later (follow-up). Hemoglobin (Hb) and hematocrit (Hct) levels in men with high serum adiponectin levels were lower at follow-up than at baseline. Multiple regression analysis showed that age, body mass index, adiponectin, and glutamic-pyruvic transaminase were significantly associated with erythroid-related variables (red blood cells, Hb, and Hct) in both men and women (P <0.05). In a logistic regression analysis, adiponectin, fasting blood glucose, and β-natriuretic peptide were significant risk factors for anemia in men, and blood urea nitrogen and amylase were significant risk factors in women. Physical features and nutrient intake were not risk factors for anemia. Our study demonstrates, both clinically and epidemiologically, that a high serum adiponectin level decreases the amounts of erythroid-related variables and is a risk factor for anemia in Japanese men.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27918575</pmid><doi>10.1371/journal.pone.0165511</doi><tpages>e0165511</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-12, Vol.11 (12), p.e0165511-e0165511 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1846008974 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abnormalities Adiponectin Adiponectin - blood Adult Aged Aged, 80 and over Alanine Transaminase - metabolism Amylases - metabolism Analysis Anemia Anemia - blood Anemia - etiology Anemia - metabolism Asian Continental Ancestry Group Atherosclerosis Biology and Life Sciences Blood Blood cells Blood Glucose - metabolism Blood tests Blood Urea Nitrogen Body mass Body mass index Body measurements Body size Bone marrow Cell adhesion & migration Diabetes Endocrinology Epidemiology Erythrocytes Female Follow-Up Studies Health aspects Health risk assessment Hematocrit Hematocrit - methods Hematology Hematopoiesis Hemoglobin Hemoglobins - metabolism Humans Insulin Internal medicine Iron Kidney diseases Laboratories Levels Male Medicine Medicine and Health Sciences Men Metabolism Middle age Middle Aged Multiple regression analysis Multivariate Analysis Neurology Nutrition Nutrition research Observational studies Older people Peptides Physical Sciences Polycythemia Prospective Studies Proteins Public health Regression Analysis Research and Analysis Methods Risk analysis Risk Factors Studies Transaminase University graduates Urea Womens health |
| title | High Serum Adiponectin Level Is a Risk Factor for Anemia in Japanese Men: A Prospective Observational Study of 1,029 Japanese Subjects |
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